Area of research
Molecular Biology · Cellular and Molecular Neuroscience
Research interest
Research interests include Genetic Neurodegenerative Diseases, Mitochondrial Function and Pathology, Alzheimer's disease research and treatments, and Bioinformatics and Genomic Networks.
Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson’s disease
MeCP2 interacts with the super elongation complex to regulate transcription
Evolutionarily conserved regulators of tau identify targets for new therapies
Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1
Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis
Dual targeting of brain region‐specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1
Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach
High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration
Integrated genomics and proteomics define huntingtin CAG length–dependent networks in mice
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington’s disease
RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1
Identification of NUB1 as a suppressor of mutant Huntingtin toxicity via enhanced protein clearance
Network Organization of the Huntingtin Proteomic Interactome in Mammalian Brain