Area of research
Molecular Biology · Genetics
Research interest
Research interests include RNA modifications and cancer, Glioma Diagnosis and Treatment, Microtubule and mitosis dynamics, and Cancer-related molecular mechanisms research.
Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
ZFTA–RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma
Energy-stress-mediated AMPK activation inhibits ferroptosis
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy
Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms
Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
Enhancer invasion shapes MYCN-dependent transcriptional amplification in neuroblastoma
Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns
A molecular portrait of epithelial–mesenchymal plasticity in prostate cancer associated with clinical outcome
Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression
A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach
A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation
TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau
Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells
A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors
Elevated CDCP1 predicts poor patient outcome and mediates ovarian clear cell carcinoma by promoting tumor spheroid formation, cell migration and chemoresistance
MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis
Control of Alveolar Differentiation by the Lineage Transcription Factors GATA6 and HOPX Inhibits Lung Adenocarcinoma Metastasis
RAS–MAPK–MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1
A role for PVRL4-driven cell–cell interactions in tumorigenesis
An Animal Model of MYC-Driven Medulloblastoma