Area of research
Molecular Biology · Oncology
Research interest
Research interests include DNA Repair Mechanisms, Ubiquitin and proteasome pathways, Cancer-related Molecular Pathways, and Microtubule and mitosis dynamics.
Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis
An RNA splicing system that excises DNA transposons from animal mRNAs.
Changes in the Transcriptome and Synthetic Lethal Dependencies Following
<i>KRAS</i>
Mutant Expression Reveal Profound Tissue-Specificity
Degrons: defining the rules of protein degradation
High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits.
Degrons: defining the rules of protein degradation.
Epstein-Barr Virus Exposure Precedes Crohn's Disease Development
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype
Cell enlargement modulated by GATA4 and YAP instructs the senescence-associated secretory phenotype.
An RNA splicing system that excises DNA transposons from animal mRNAs
Structure of the TXNL1-bound proteasome.
Aneuploidy generates enhanced nucleotide dependency and sensitivity to metabolic perturbation.
Structure of the TXNL1-bound proteasome
Conserved CD8 T cell vaccines without B cell epitopes drive robust protection against SARS-CoV-2 that is enhanced by intranasal boost.
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns
Chromosome evolution screens recapitulate tissue-specific tumor aneuploidy patterns.
High-throughput discovery of MHC class I- and II-restricted T cell epitopes using synthetic cellular circuits
Serologic Response to the Epstein-Barr Virus Peptidome and the Risk for Multiple Sclerosis
Rapid iPSC inclusionopathy models shed light on formation, consequence, and molecular subtype of α-synuclein inclusions
Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2
Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer.
Mechanism of Ψ-Pro/C-degron recognition by the CRL2FEM1B ubiquitin ligase
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Mechanism of Ψ-Pro/C-degron recognition by the CRL2<sup>FEM1B</sup> ubiquitin ligase.
Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability
Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability.
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases