Area of research
Oncology · Immunology
Research interest
Research interests include Cancer Cells and Metastasis, Cancer Immunotherapy and Biomarkers, Bone health and treatments, and Immune cells in cancer.
Invasion and metastasis in cancer: molecular insights and therapeutic targets
Integrative spatial omics reveals distinct tumor-promoting multicellular niches and immunosuppressive mechanisms in Black American and White American patients with TNBC
Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
The bone microenvironment invigorates metastatic seeds for further dissemination
Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer
Evolving cancer–niche interactions and therapeutic targets during bone metastasis
The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells
Lung mesenchymal cells elicit lipid storage in neutrophils that fuel breast cancer lung metastasis
Tumor-Associated Neutrophils and Macrophages—Heterogenous but Not Chaotic
Resistance to natural killer cell immunosurveillance confers a selective advantage to polyclonal metastasis
Metastasis Organotropism: Redefining the Congenial Soil
Immuno-subtyping of breast cancer reveals distinct myeloid cell profiles and immunotherapy resistance mechanisms
Bone Metastasis: Find Your Niche and Fit in
Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer
Perspective on Circulating Tumor Cell Clusters: Why It Takes a Village to Metastasize
The Osteogenic Niche Is a Calcium Reservoir of Bone Micrometastases and Confers Unexpected Therapeutic Vulnerability
HER2/EGFR–AKT Signaling Switches TGFβ from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer
Targeting Brain-Adaptive Cancer Stem Cells Prohibits Brain Metastatic Colonization of Triple-Negative Breast Cancer
Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
Oncogenic mTOR signalling recruits myeloid-derived suppressor cells to promote tumour initiation
The spliceosome is a therapeutic vulnerability in MYC-driven cancer
The Osteogenic Niche Promotes Early-Stage Bone Colonization of Disseminated Breast Cancer Cells
14-3-3ζ Turns TGF-β’s Function from Tumor Suppressor to Metastasis Promoter in Breast Cancer by Contextual Changes of Smad Partners from p53 to Gli2
Serpins Promote Cancer Cell Survival and Vascular Co-Option in Brain Metastasis
Selection of Bone Metastasis Seeds by Mesenchymal Signals in the Primary Tumor Stroma
Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation
Collaborative Research: III: Small: An Information-Theoretic Framework for Explainable and Explanation-Assisted Graph Learning
CAREER: Multiscale Reduced Order Modeling and Design to Elucidate the Microstructure-Property-Performance Relationship of Hybrid Composite Materials
CRII:SCH:Self-Supervised Contrastive Representation Learning for Medical Time Series
Collaborative Research: An Integrated Multiscale Reduced-Order Modeling and Experimental Framework for Lithium-ion Batteries under Mechanical Abuse Conditions
MRI: Acquisition of a Low-Vibration, Cryogen-Free Cryostat Microscope System
EAGER: Advancing High-Efficiency Nanoscale Antiferromagnetic Spintronics with Two-Dimensional Half Metals
CAREER: Novel Approaches for Mining Large and Complex Networks
CAREER: Novel Approaches for Mining Large and Complex Networks
III: Medium: Collaborative Research: Toward Robust and Scalable Discovering of Significant Associations in Massive Genetic Data
INSPIRE Track 1: Exploring New Route of Optically Mediated Self-Assembly: Final Material Properties Determine Its Structures
III: Medium: Collaborative Research: Toward Robust and Scalable Discovering of Significant Associations in Massive Genetic Data
III: Small: Mining Local Correlations in Extremely High-Dimensional Data: Models, Algorithms, and Applications
Materials World Network: Classical and Quantum Optical Metamaterials by Combining Top-down and Bottom-up Fabrication Techniques
NSEC: Center for Scalable and Integrated Nanomanufacturing (SINAM)
Development of Novel 3D Nano Lithography: Fundamental Investigations and Applications
SST/Collaborative Research: Self-Supporting Wireless Sensor Networks for In-Process and In-Service Integrity Monitoring Using High Energy-Harvesting Nonlinear Modeling Principles
NSEC: Center for Scalable and Integrated Nano Manufacturing (SINAM)
MRI: 3D Nano Manufacturing of Novel Photonic Structures
Development of Novel 3D Nano Lithography: Fundamental Investigations and Applications
CAREER: Non-Integrated Circuits Micro-Manufacturing: Integrated Research and Education
CAREER: Non-Integrated Circuits Micro-Manufacturing: Integrated Research and Education