Area of research
Cancer Research · Oncology
Research interest
Research interests include Computational biology, Matrix metalloproteinase, Chemistry, Matrix metalloproteinase inhibitor, Binding affinities, and Binding site.
Engineered TIMP2 with narrow MMP-9 specificity is an effective inhibitor of invasion and proliferation of triple-negative breast cancer cells
Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension
Climbing Up and Down Binding Landscapes through Deep Mutational Scanning of Three Homologous Protein–Protein Complexes
Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of <scp>MMP</scp> ‐9 and <scp>MMP</scp> ‐14
Development of High Affinity and High Specificity Inhibitors of Matrix Metalloproteinase 14 through Computational Design and Directed Evolution
Cold Spots in Protein Binding
Combinatorial and Computational Approaches to Identify Interactions of Macrophage Colony-stimulating Factor (M-CSF) and Its Receptor c-FMS
Affinity- and Specificity-Enhancing Mutations Are Frequent in Multispecific Interactions between TIMP2 and MMPs
Mapping of the Binding Landscape for a Picomolar Protein-Protein Complex through Computation and Experiment
Predicting affinity- and specificity-enhancing mutations at protein–protein interfaces