Area of research
Aging · Cell Biology
Research interest
Research interests include Genetics, Aging, and Longevity in Model Organisms, Endoplasmic Reticulum Stress and Disease, Mitochondrial Function and Pathology, and Adipose Tissue and Metabolism.
Translational regulation in stress biology
Age-related remodeling of the sialoglycans dampens murine CD8 <sup>+</sup> T cell function
Cross-Organ Mitochondrial Communication in Stress and Disease
The extracellular matrix integrates mitochondrial homeostasis
The germline coordinates mitokine signaling
Cell non-autonomous control of autophagy and metabolism by glial cells
CRISPR screens and lectin microarrays identify high mannose N-glycan regulators
Perception of a pathogenic signature initiates intergenerational protection
Olfaction regulates peripheral mitophagy and mitochondrial function
Glial-derived mitochondrial signals affect neuronal proteostasis and aging
Inter-tissue communication of mitochondrial stress and metabolic health
Lipid homeostasis is essential for a maximal ER stress response
The germline coordinates mitokine signaling
The UPRmt preserves mitochondrial import to extend lifespan
A class of anti-inflammatory lipids decrease with aging in the central nervous system
Glia of <i>C. elegans</i> coordinate a protective organismal heat shock response independent of the neuronal thermosensory circuit
Macroautophagy in quiescent and senescent cells: a pathway to longevity?
SKN-1 regulates stress resistance downstream of amino catabolism pathways
Life in lockdown: Orchestrating endoplasmic reticulum and lysosome homeostasis for quiescent cells
Adhesion-mediated mechanosignaling forces mitohormesis
Measuring expression heterogeneity of single-cell cytoskeletal protein complexes
Cross-species screening platforms identify EPS-8 as a critical link for mitochondrial stress and actin stabilization
Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in <i>C. elegans</i>
Beyond the cell factory: Homeostatic regulation of and by the UPR <sup>ER</sup>
Systemic effects of mitochondrial stress
UPR <sup>ER</sup> promotes lipophagy independent of chaperones to extend life span
Divergent Nodes of Non-autonomous UPRER Signaling through Serotonergic and Dopaminergic Neurons
Lysosomal recycling of amino acids affects ER quality control
Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction
The Hyaluronidase, TMEM2, Promotes ER Homeostasis and Longevity Independent of the UPRER