Area of research
Parasitology · Public Health, Environmental and Occupational Health
Research interest
Research interests include Parasites and Host Interactions, Research on Leishmaniasis Studies, Parasite Biology and Host Interactions, and Trypanosoma species research and implications.
The Kavaratamides: Discovery of Linear Lipodepsipeptides from the Marine Cyanobacterium <i>Moorena bouillonii</i> Using a Comparative Chemogeographic Analysis
Perspective on Schistosomiasis Drug Discovery: Highlights from a Schistosomiasis Drug Discovery Workshop at Wellcome Collection, London, September 2022
Protein–protein interactions: developing small-molecule inhibitors/stabilizers through covalent strategies
Anti-schistosomal activities of quinoxaline-containing compounds: From hit identification to lead optimisation
A single-cell RNA-seq atlas of <i>Schistosoma mansoni</i> identifies a key regulator of blood feeding
Novel and selective inactivators of Triosephosphate isomerase with anti-trematode activity
Cysteine proteases as digestive enzymes in parasitic helminths
Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties
Cysteine proteases during larval migration and development of helminths in their final host
Targeting proteasomes in infectious organisms to combat disease
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Sex-Biased Transcriptome of Schistosoma mansoni: Host-Parasite Interaction, Genetic Determinants and Epigenetic Regulators Are Associated with Sexual Differentiation
Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni
Caenorhabditis elegans is a useful model for anthelmintic discovery
Schistosomiasis and Its Treatment
Synthesis of a Sugar-Based Thiosemicarbazone Series and Structure-Activity Relationship versus the Parasite Cysteine Proteases Rhodesain, Cruzain, and Schistosoma mansoni Cathepsin B1
Excretion/secretion products from Schistosoma mansoni adults, eggs and schistosomula have unique peptidase specificity profiles
Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis
Regulation of Schistosoma mansoni Development and Reproduction by the Mitogen-Activated Protein Kinase Signaling Pathway
Trypsin- and Chymotrypsin-Like Serine Proteases in Schistosoma mansoni – ‘The Undiscovered Country’
Activation Route of the Schistosoma mansoni Cathepsin B1 Drug Target: Structural Map with a Glycosaminoglycan Switch
New insights into the machinery of blood digestion by ticks
A Cysteine Protease Inhibitor Rescues Mice from a Lethal Cryptosporidium parvum Infection
Trypanosoma brucei: Chemical evidence that cathepsin L is essential for survival and a relevant drug target
Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis