Area of research
Neurology · Physiology
Research interest
Research interests include Barrier Structure and Function Studies, Alzheimer's disease research and treatments, Neurological Disease Mechanisms and Treatments, and Lipid Membrane Structure and Behavior.
APOE-Targeted Therapeutics for Alzheimer's Disease
Pericyte loss leads to circulatory failure and pleiotrophin depletion causing neuron loss
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain
Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain
Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance