Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Polyamine Metabolism and Applications, PI3K/AKT/mTOR signaling in cancer, Cellular transport and secretion, and Pain Mechanisms and Treatments.
DRG afferents that mediate physiologic and pathologic mechanosensation from the distal colon
Parallel ascending spinal pathways for affective touch and pain
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
A mouse model of DEPDC5-related epilepsy: Neuronal loss of Depdc5 causes dysplastic and ectopic neurons, increased mTOR signaling, and seizure susceptibility
Sestrin2 is a leucine sensor for the mTORC1 pathway
Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.
Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
Nutrient-Sensing Mechanisms across Evolution
Recurrent mTORC1-activating RRAGC mutations in follicular lymphoma
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival