Jose M. Orozco — Harvard University

Area of research

Molecular Biology

Research interest

Research interests include PI3K/AKT/mTOR signaling in cancer, CRISPR and Genetic Engineering, Mitochondrial Function and Pathology, and Polyamine Metabolism and Applications.

Recent publications

The intrinsic substrate specificity of the human tyrosine kinome

Nature 2024cited by 137position: middledoi

Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction

Proceedings of the National Academy of Sciences 2021cited by 129position: middledoi

Dihydroxyacetone phosphate signals glucose availability to mTORC1

Nature Metabolism 2020cited by 234position: firstdoi

SAMTOR is an <i>S</i> -adenosylmethionine sensor for the mTORC1 pathway

Science 2017cited by 541position: middledoi

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

Nature 2017cited by 319position: middledoi

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Cell Reports 2014cited by 452position: middledoi

Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants

Proceedings of the National Academy of Sciences 2013cited by 738position: middledoi

Grants

Metal Foam as Heat Transfer Enhancement Devices

NSF9320416$255,6401994–1996PIRePORTER

Metal Foams as Heat Transfer Enhancement Device

NSF9261687$50,0001993–1993PIRePORTER

Engineering Research Equipment: Experimental Studies in Heat Transfer

NSF8906821$28,0001989–1990PIRePORTER

Research Initiation: Experimental Studies of Film and Transition Boiling Heat Transfer

NSF8808988$79,9241988–1991PIRePORTER

Frequent collaborators

David M. Sabatini · Czech Academy of Sciences5 papers (2014–2021)Sonia M. Scaria · University of California, San Francisco4 papers (2014–2020)Kendall J. Condon · Bristol-Myers Squibb (Germany)3 papers (2017–2021)Xin Gu · Harvard University2 papers (2017–2017)Lynne Chantranupong · Howard Hughes Medical Institute2 papers (2014–2017)Rachel L. Wolfson · Harvard University2 papers (2014–2017)Patrycja A. Krawczyk · MRC Laboratory of Molecular Biology2 papers (2017–2020)Tenzin Kunchok · Massachusetts Institute of Technology2 papers (2020–2021)Robert A. Saxton · University of California, Berkeley2 papers (2014–2017)Steven P. Gygi · Harvard University2 papers (2014–2017)Robert A. Saxton · Massachusetts Institute of Technology1 papers (2017–2017)Liron Bar‐Peled · Harvard University1 papers (2014–2014)Sabrina Petri · Columbia University1 papers (2017–2017)Kuang Shen · University of Southampton1 papers (2017–2017)Eric Spooner · Massachusetts Institute of Technology1 papers (2014–2014)Marta Isasa · Harvard Stem Cell Institute1 papers (2014–2014)Gregory A. Wyant · Harvard University1 papers (2017–2017)Caroline A. Lewis · University of Massachusetts Chan Medical School1 papers (2020–2020)Andrew L. Cangelosi · Duke Medical Center1 papers (2020–2020)Charles H. Adelmann · IIT@MIT1 papers (2021–2021)

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