Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Ubiquitin and proteasome pathways, Cellular transport and secretion, PI3K/AKT/mTOR signaling in cancer, and Nitric Oxide and Endothelin Effects.
Structural basis for the midnolin-proteasome pathway and its role in suppressing myeloma
Structure of the TXNL1-bound proteasome
Rag–Ragulator is the central organizer of the physical architecture of the mTORC1 nutrient-sensing pathway
The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation
A central role for regulated protein stability in the control of TFE3 and MITF by nutrients
Structure of the nutrient-sensing hub GATOR2
Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
Author Correction: Sestrin mediates detection of and adaptation to low-leucine diets in Drosophila
Structural basis for the docking of mTORC1 on the lysosomal surface
Arg-78 of Nprl2 catalyzes GATOR1-stimulated GTP hydrolysis by the Rag GTPases
Cryo-EM structure of human rhodopsin bound to an inhibitory G protein
SAMTOR is an <i>S</i> -adenosylmethionine sensor for the mTORC1 pathway
A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Structural basis of AMPK regulation by adenine nucleotides and glycogen
Structural basis for RNA recognition by a dimeric PPR-protein complex