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Alissa M. D’Gama

Boston Children's Hospital · US
Area of research
Genetics · Psychiatry and Mental health
Research interest
Research interests include Genomics and Rare Diseases, Genetics and Neurodevelopmental Disorders, Genomic variations and chromosomal abnormalities, and Epilepsy research and treatment.
h-index
25
citations
4,261
works
86
NIH funding
primary concept
email

Recent publications

Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption
Nature Genetics 2025cited by 37position: middledoi
Cell-type-informed genotyping of mosaic focal epilepsies reveals cell-autonomous and non-cell-autonomous disease-associated transcriptional programs
Proceedings of the National Academy of Sciences 2025cited by 10position: middledoi
Analysis of DNA from brain tissue on stereo-EEG electrodes reveals mosaic epilepsy-related variants
Brain Communications 2025cited by 6position: firstdoi
Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development
Nature Genetics 2023cited by 109position: middledoi
Control-independent mosaic single nucleotide variant detection with DeepMosaic
Nature Biotechnology 2023cited by 39position: middledoi
Genomic data resources of the Brain Somatic Mosaicism Network for neuropsychiatric diseases
Scientific Data 2023cited by 5position: middledoi
Author Correction: Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia
Nature Neuroscience 2023cited by 0position: middledoi
Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing
Nature Neuroscience 2023cited by 0position: middledoi
Analysis of somatic mutations in 131 human brains reveals aging-associated hypermutability
Science 2022cited by 71position: middledoi
Somatic mosaicism reveals clonal distributions of neocortical development
Nature 2022cited by 61position: middledoi
The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing
Nature Neuroscience 2021cited by 133position: middledoi
Machine learning reveals bilateral distribution of somatic L1 insertions in human neurons and glia
Nature Neuroscience 2021cited by 36position: middledoi
Author Correction: The landscape of somatic mutation in cerebral cortex of autistic and neurotypical individuals revealed by ultra-deep whole-genome sequencing
Nature Neuroscience 2021cited by 9position: middledoi
The Landscape of Mutational Mosaicism in Autistic and Normal Human Cerebral Cortex
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 13position: middledoi
Exome sequencing identifies novel missense and deletion variants in <scp><i>RTN4IP1</i></scp> associated with optic atrophy, global developmental delay, epilepsy, ataxia, and choreoathetosis
American Journal of Medical Genetics Part A 2020cited by 10position: firstdoi
Publisher Correction: Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder
Nature Neuroscience 2020cited by 0position: middledoi
Somatic mosaicism and neurodevelopmental disease
Nature Neuroscience 2018cited by 246position: firstdoi
Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias
Cell Reports 2017cited by 332position: firstdoi
Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder
Nature Neuroscience 2017cited by 309position: middledoi
Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network
Science 2017cited by 280position: middledoi
Biallelic mutations in human DCC cause developmental split-brain syndrome
Nature Genetics 2017cited by 79position: middledoi
Somatic Mosaicism and Neurological Diseases
Elsevier eBooks 2016cited by 9position: middledoi
Somatic mutation in single human neurons tracks developmental and transcriptional history
Science 2015cited by 583position: middledoi
Mammalian target of rapamycin pathway mutations cause hemimegalencephaly and focal cortical dysplasia
Annals of Neurology 2015cited by 285position: firstdoi
Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms
Neuron 2015cited by 156position: firstdoi
Somatic Mutations in Cerebral Cortical Malformations
New England Journal of Medicine 2014cited by 394position: middledoi
Using Whole-Exome Sequencing to Identify Inherited Causes of Autism
Neuron 2013cited by 458position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Christopher A. Walsh · Boston Children's Hospital10 papers (2015–2025)Annapurna Poduri · Broad Institute4 papers (2015–2025)Peter J. Park · Broad Institute3 papers (2015–2021)Lovelace J. Luquette · IIT@MIT3 papers (2015–2021)Rachel E. Rodin · Brigham and Women's Hospital2 papers (2020–2021)A. James Barkovich · University of California, San Francisco2 papers (2015–2017)Ingmar Blümcke · Case Western Reserve University2 papers (2017–2025)Nicole E. Hatem · Suez Canal University2 papers (2015–2017) · 2 papers (2020–2021)Edward Yang · Insper2 papers (2017–2025)Sara Bizzotto · Centre National de la Recherche Scientifique2 papers (2017–2025)Sanjay P. Prabhu · University of Illinois Chicago2 papers (2020–2025)Harry V. Vinters · University of California System2 papers (2015–2017)August Yue Huang · Broad Institute2 papers (2025–2025)Lariza M. Rento · Boston Children's Hospital2 papers (2020–2021)Gary W. Mathern · University of California, Los Angeles2 papers (2015–2017)Amer A. Hossain · Rockefeller University2 papers (2015–2017)D. Gulhan · Broad Institute2 papers (2020–2021)Kelly M. Girskis · Boston Children's Hospital2 papers (2020–2021) · 2 papers (2015–2017)