Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include Biology, Induced pluripotent stem cell, Haematopoiesis, Immunology, Pulmonary alveolar proteinosis, and Cell biology.
FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice
Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions
Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia
Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors
Beyond “Big Eaters”: The Versatile Role of Alveolar Macrophages in Health and Disease
Human iPSC-derived macrophages for efficient<i>Staphylococcus aureus</i>clearance in a murine pulmonary infection model
Restored Macrophage Function Ameliorates Disease Pathophysiology in a Mouse Model for IL10 Receptor-deficient Very Early Onset Inflammatory Bowel Disease
A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification
Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency
Enhanced Ex Vivo Generation of Erythroid Cells from Human Induced Pluripotent Stem Cells in a Simplified Cell Culture System with Low Cytokine Support
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections
Pulmonary Transplantation of Human Induced Pluripotent Stem Cell–derived Macrophages Ameliorates Pulmonary Alveolar Proteinosis
iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice
Concise Review: Towards the Clinical Translation of Induced Pluripotent Stem Cell-Derived Blood Cells—<i>Ready for Take-Off</i>
Impaired IFNγ-Signaling and Mycobacterial Clearance in IFNγR1-Deficient Human iPSC-Derived Macrophages
TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosis
Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells
Identification and characterization of novel functional markers of EHT
Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies
Lost in translation: pluripotent stem cell‐derived hematopoiesis
A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells
TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells
Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis
Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy