Area of research
Molecular Biology · Hepatology
Research interest
Research interests include Biology, Induced pluripotent stem cell, Cell biology, Reprogramming, Hepatocyte, and microRNA.
A spatiotemporal atlas of mouse liver homeostasis and regeneration
Identification and functional validation of miR-190b-5p and miR-296-3p as novel therapeutic attenuators of liver fibrosis
Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model
KIF12 Variants and Disturbed Hepatocyte Polarity in Children with a Phenotypic Spectrum of Cholestatic Liver Disease
A selectable all-in-one CRISPR prime editing piggyBac transposon allows for highly efficient gene editing in human cell lines
Human germline editing in the era of CRISPR-Cas: risk and uncertainty, inter-generational responsibility, therapeutic legitimacy
Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells
Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations
Genome-wide tracking of dCas9-methyltransferase footprints
A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features
Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells
Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis
Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming
Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase
MicroRNA-125b-5p mimic inhibits acute liver failure
Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG)
Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts
Concise Review: Cell Therapies for Hereditary Metabolic Liver Diseases—Concepts, Clinical Results, and Future Developments
MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells
Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis
A ubiquitous chromatin opening element prevents transgene silencing in pluripotent stem cells and their differentiated progeny
Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy
Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy
Improved Hepatic Differentiation Strategies for Human Induced Pluripotent Stem Cells
MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration
Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells
Increased Reprogramming Capacity of Mouse Liver Progenitor Cells, Compared With Differentiated Liver Cells, Requires the BAF Complex