Area of research
Rheumatology · Physiology
Research interest
How far we have come. Osteoarthritis Cartilage. 2024 Jul; 32(7):858-868. PMID: 38428513 Rai MF, Collins KH, Lang A, Maerz T, Geurts J, Ruiz-Romero C, June RK, Ramos Y, Rice SJ, Ali SA, Pastrello C, Jurisica I, Thomas Appleton C, Rockel JS, Kapoor M. Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies. Osteoarthritis Cartilage. 2024 Apr; 32(4):385-397. PMID: 38049029 Abughazaleh N, Boldt K, Rios JL, Mattiello SM, Collins KH, Seerattan RA, Herzog W. Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat-High-Sucrose Diet in a Rat Model. Cartilage. 2024 Dec; 15(4):453-460. PMID: 37655800 Buettmann EG, Chlebek C, Lockard CA, Clayton SW, Lewis KJ, Collins KH. Post or perish? Social media
Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain
Osteoarthritis as a systemic disease
Collins KH, Lenz KL, Welhaven HD, Ely E, Springer LE, Paradi S, Tang R, Braxton L, Akk A, Yan H, Zhang B, Wu X, Atkinson JP, Oestreich AK, June RK, Pham CTN, Guilak F. Adipose-derived leptin and complement factor D mediate osteoarthritis severity and pain. Sci Adv. 2025 Apr 25; 11(17):eadt5915. PMID
— 2025cited by 0position: selected
Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery
Klimak M, Cimino A, Lenz KL, Springer LE, Collins KH, Harasymowicz NS, Xu N, Pham CTN, Guilak F. Engineered self-regulating macrophages for targeted anti-inflammatory drug delivery. Arthritis Res Ther. 2024 Nov 06; 26(1):190. PMID: 39501398
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Shen KC, Collins KH, Ferey JLA, Fappi A, McCormick JJ, Mittendorfer B, Guilak F, Meyer GA. Excess Intramyocellular Lipid Does Not Affect Muscle Fiber Biophysical Properties in Mice or People With Metabolically Abnormal Obesity. Diabetes. 2024 Aug 01; 73(8):1266-1277. PMID: 38701374
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Karjalainen K, Tanska P, Collins KH, Herzog W, Korhonen RK, Moo EK. Independent and combined effects of obesity and traumatic joint injury to the structure and composition of rat knee cartilage. Connect Tissue Res. 2024 03; 65(2):117-132. PMID: 38530304
— 2024cited by 0position: selected
Abughazaleh N, Boldt K, Rios JL, Mattiello SM, Collins KH, Seerattan RA, Herzog W. Aerobic and Resistance Training Attenuate Differently Knee Joint Damage Caused by a High-Fat-High-Sucrose Diet in a Rat Model. Cartilage. 2024 Dec; 15(4):453-460. PMID: 37655800
— 2024cited by 0position: selected
Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies
Collins KH, Pferdehirt L, Saleh LS, Savadipour A, Springer LE, Lenz KL, Thompson DM, Oswald SJ, Pham CTN, Guilak F. Hydrogel Encapsulation of Genome-Engineered Stem Cells for Long-Term Self-Regulating Anti-Cytokine Therapy. Gels. 2023 Feb 20; 9(2). PMID: 36826339
— 2023cited by 0position: selected
Savadipour A, Palmer D, Ely EV, Collins KH, Garcia-Castorena JM, Harissa Z, Kim YS, Oestrich A, Qu F, Rashidi N, Guilak F. The role of PIEZO ion channels in the musculoskeletal system. Am J Physiol Cell Physiol. 2023 03 01; 324(3):C728-C740. PMID: 36717101
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Halvorson RT, Allahabadi S, Cevallos N, Foley AJ, Collins K, Torres Espin A, Feeley BT, Pandya NK, Bailey JF. #OrthoTwitter: Relationship Between Author Twitter Utilization and Academic Impact in Orthopaedic Surgery. Cureus. 2023 Jan; 15(1):e33978. PMID: 36814734
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Collins KH, Guilak F. Trimming the fat - is leptin crosstalk the link between obesity and osteoarthritis? Osteoarthritis Cartilage. 2023 01; 31(1):23-25. PMID: 36273787
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Collins KH, Gui C, Ely EV, Lenz KL, Harris CA, Guilak F, Meyer GA. Leptin mediates the regulation of muscle mass and strength by adipose tissue. J Physiol. 2022 08; 600(16):3795-3817. PMID: 35844058
— 2022cited by 0position: selected
Choi YR, Collins KH, Springer LE, Pferdehirt L, Ross AK, Wu CL, Moutos FT, Harasymowicz NS, Brunger JM, Pham CTN, Guilak F. A genome-engineered bioartificial implant for autoregulated anticytokine drug delivery. Sci Adv. 2021 Sep 03; 7(36):eabj1414. PMID: 34516920
— 2021cited by 0position: selected
Collins KH, Schwartz DJ, Lenz KL, Harris CA, Guilak F. Taxonomic changes in the gut microbiota are associated with cartilage damage independent of adiposity, high fat diet, and joint injury. Sci Rep. 2021 07 15; 11(1):14560. PMID: 34267289
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Smith IC, Ostertag C, O'Reilly JJ, Rios JL, Klancic T, MacDonald GZ, Collins KH, Reimer RA, Herzog W. Contractility of permeabilized rat vastus intermedius muscle fibres following high-fat, high-sucrose diet consumption. Appl Physiol Nutr Metab. 2021 Nov; 46(11):1389-1399. PMID: 34139131
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Klimak M, Nims RJ, Pferdehirt L, Collins KH, Harasymowicz NS, Oswald SJ, Setton LA, Guilak F. Immunoengineering the next generation of arthritis therapies. Acta Biomater. 2021 10 01; 133:74-86. PMID: 33823324
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Collins KH, Lenz KL, Pollitt EN, Ferguson D, Hutson I, Springer LE, Oestreich AK, Tang R, Choi YR, Meyer GA, Teitelbaum SL, Pham CTN, Harris CA, Guilak F. Adipose tissue is a critical regulator of osteoarthritis. Proc Natl Acad Sci U S A. 2021 01 05; 118(1). PMID: 33443201
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Oestreich AK, Collins KH, Harasymowicz NS, Wu CL, Guilak F. Is Obesity a Disease of Stem Cells? Cell Stem Cell. 2020 07 02; 27(1):15-18. PMID: 32619511
— 2020cited by 0position: selected
Biltz NK, Collins KH, Shen KC, Schwartz K, Harris CA, Meyer GA. Infiltration of intramuscular adipose tissue impairs skeletal muscle contraction. J Physiol. 2020 07; 598(13):2669-2683. PMID: 32358797
— 2020cited by 0position: selected
Tang R, Harasymowicz NS, Wu CL, Collins KH, Choi YR, Oswald SJ, Guilak F. Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity. Sci Adv. 2020 05; 6(19):eaaz7492. PMID: 32426485
— 2020cited by 0position: selected
Wu CL, Harasymowicz NS, Klimak MA, Collins KH, Guilak F. The role of macrophages in osteoarthritis and cartilage repair. Osteoarthritis Cartilage. 2020 05; 28(5):544-554. PMID: 31926267
— 2020cited by 0position: selected
Collins KH, MacDonald GZ, Hart DA, Seerattan RA, Rios JL, Reimer RA, Herzog W. Impact of age on host responses to diet-induced obesity: Development of joint damage and metabolic set points. J Sport Health Sci. 2020 03; 9(2):132-139. PMID: 32099721
— 2020cited by 0position: selected
Guilak F, Pferdehirt L, Ross AK, Choi YR, Collins K, Nims RJ, Katz DB, Klimak M, Tabbaa S, Pham CTN. Designer Stem Cells: Genome Engineering and the Next Generation of Cell-Based Therapies. J Orthop Res. 2019 06; 37(6):1287-1293. PMID: 30977548
— 2019cited by 0position: selected
Rios JL, Bomhof MR, Reimer RA, Hart DA, Collins KH, Herzog W. Protective effect of prebiotic and exercise intervention on knee health in a rat model of diet-induced obesity. Sci Rep. 2019 03 07; 9(1):3893. PMID: 30846801
— 2019cited by 0position: selected
Yan H, Duan X, Collins KH, Springer LE, Guilak F, Wickline SA, Rai MF, Pan H, Pham CTN. Nanotherapy Targeting NF-κB Attenuates Acute Pain After Joint Injury. Precis Nanomed. 2019; 2(1):245-248. PMID: 31681908
— 2019cited by 0position: selected
Paul HA, Collins KH, Nicolucci AC, Urbanski SJ, Hart DA, Vogel HJ, Reimer RA. Maternal prebiotic supplementation reduces fatty liver development in offspring through altered microbial and metabolomic profiles in rats. FASEB J. 2019 04; 33(4):5153-5167. PMID: 30629464
— 2019cited by 0position: selected
Choi YR, Collins KH, Lee JW, Kang HJ, Guilak F. Genome Engineering for Osteoarthritis: From Designer Cells to Disease-Modifying Drugs. Tissue Eng Regen Med. 2019 08; 16(4):335-343. PMID: 31413938
— 2019cited by 0position: selected
Obesity, Metabolic Syndrome, and Musculoskeletal Disease: Common Inflammatory Pathways Suggest a Central Role for Loss of Muscle Integrity