Area of research
Neurology · Cellular and Molecular Neuroscience
Research interest
Research interests include LRRK2, Neuroscience, Dopaminergic, Biology, Substantia nigra, and Dopamine.
Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation
Nuclear ASC speck formation in microglia is associated with inflammasome priming and is exacerbated in LRRK2-G2019S Parkinson’s disease
Dopamine Transporter, PhosphoSerine129 α-Synuclein and α-Synuclein Levels in Aged LRRK2 G2019S Knock-In and Knock-Out Mice
Mitochondrial P2X7 Receptor Localization Modulates Energy Metabolism Enhancing Physical Performance
In vivo susceptibility to energy failure parkinsonism and LRRK2 kinase activity
Early Dysfunction of Substantia Nigra Dopamine Neurons in the ParkinQ311X Mouse
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in nonhuman primates
Safinamide inhibits in vivo glutamate release in a rat model of Parkinson's disease
Pharmacological antagonism of kainate receptor rescues dysfunction and loss of dopamine neurons in a mouse model of human parkin-induced toxicity
Pharmacological Antagonism of Kainate Receptor Rescues Dysfunction and Loss of Dopamine Neurons in a Mouse Model of Human Parkin-induced Toxicity
The P2X7 receptor localizes to the mitochondria, modulates mitochondrial energy metabolism and enhances physical performance
Autophagy and LRRK2 in the Aging Brain
Identification of distinct pathological signatures induced by patient-derived α-synuclein structures in non-human primates
G2019S LRRK2 mutation facilitates α-synuclein neuropathology in aged mice
Safinamide Modulates Striatal Glutamatergic Signaling in a Rat Model of Levodopa-Induced Dyskinesia
Dopamine D2 receptor activation potently inhibits striatal glutamatergic transmission in a G2019S LRRK2 genetic model of Parkinson's disease
NOP Receptor Ligands and Parkinson’s Disease
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia
Anti‐Parkinsonian and anti‐dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists