Area of research
Molecular Biology · Pharmacology
Research interest
Research interests include Microbial Natural Products and Biosynthesis, RNA and protein synthesis mechanisms, Biochemical and Structural Characterization, and Chemical Synthesis and Analysis.
Cell-free synthetic biology for natural product biosynthesis and discovery
Aminoacyl-tRNA Specificity of a Ligase Catalyzing Non-ribosomal Peptide Extension
Genome Mining for New Enzyme Chemistry
High-Yield Lasso Peptide Production in a <i>Burkholderia</i> Bacterial Host by Plasmid Copy Number Engineering
A scalable platform to discover antimicrobials of ribosomal origin
Accessing Diverse Pyridine-Based Macrocyclic Peptides by a Two-Site Recognition Pathway
New developments in RiPP discovery, enzymology and engineering
Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family
Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin
antiSMASH 4.0—improvements in chemistry prediction and gene cluster boundary identification
Structural insights into enzymatic [4+2] <i>aza</i> -cycloaddition in thiopeptide antibiotic biosynthesis
Reconstitution and Substrate Specificity of the Radical <i>S</i>-Adenosyl-methionine Thiazole <i>C</i>-Methyltransferase in Thiomuracin Biosynthesis
Mechanism of a Class C Radical <i>S</i>-Adenosyl-<scp>l</scp>-methionine Thiazole Methyl Transferase
Plantazolicin Is an Ultranarrow-Spectrum Antibiotic That Targets the<i>Bacillus anthracis</i>Membrane
Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS
Undecaprenyl Diphosphate Synthase Inhibitors: Antibacterial Drug Leads
Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature
Antibacterial drug leads targeting isoprenoid biosynthesis