← back to search

Lior Pachter

California Institute of Technology · US
Area of research
Molecular Biology
Research interest
Research interests include Single-cell and spatial transcriptomics, Genomics and Phylogenetic Studies, RNA Research and Splicing, and RNA and protein synthesis mechanisms.
h-index
81
citations
105,701
works
439
NIH funding
primary concept
Biology
email

Recent publications

Detection of viral sequences at single-cell resolution identifies novel viruses associated with host gene expression changes
Nature Biotechnology 2025cited by 8position: lastdoi
Long-read sequencing transcriptome quantification with lr-kallisto
PLoS Computational Biology 2025cited by 6position: lastdoi
The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution
Nature 2025cited by 6position: middledoi
Geospatially informed representation of spatial genomics data with SpatialFeatureExperiment
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 1position: lastdoi
PSCA-CAR T cell therapy in metastatic castration-resistant prostate cancer: a phase 1 trial
Nature Medicine 2024cited by 110position: middledoi
Deciphering the impact of genomic variation on function
Nature 2024cited by 77position: middledoi
kallisto, bustools and kb-python for quantifying bulk, single-cell and single-nucleus RNA-seq
Nature Protocols 2024cited by 47position: lastdoi
A Python library for probabilistic analysis of single-cell omics data
Nature Biotechnology 2022cited by 791position: middledoi
A multimodal cell census and atlas of the mammalian primary motor cortex
Nature 2021cited by 564position: middledoi
Modular, efficient and constant-memory single-cell RNA-seq preprocessing
Nature Biotechnology 2021cited by 492position: lastdoi
A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex
Nature 2021cited by 372position: middledoi
Whole-animal multiplexed single-cell RNA-seq reveals transcriptional shifts across <i>Clytia</i> medusa cell types
Science Advances 2021cited by 122position: lastdoi
Isoform cell-type specificity in the mouse primary motor cortex
Nature 2021cited by 91position: lastdoi
Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples
Nature Biomedical Engineering 2021cited by 75position: middledoi
An integrated transcriptomic and epigenomic atlas of mouse primary motor cortex cell types
bioRxiv (Cold Spring Harbor Laboratory) 2020cited by 63position: middledoi
Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior
Cell 2019cited by 274position: middledoi
Association mapping from sequencing reads using k-mers
eLife 2018cited by 144position: lastdoi
Gene-level differential analysis at transcript-level resolution
bioRxiv (Cold Spring Harbor Laboratory) 2017cited by 10position: lastdoi
Single-cell analysis at the threshold
Nature Biotechnology 2016cited by 72position: middledoi
Estimating intrinsic and extrinsic noise from single-cell gene expression measurements
Statistical Applications in Genetics and Molecular Biology 2016cited by 43position: lastdoi
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas
New England Journal of Medicine 2015cited by 3,216position: middledoi
The NIH BD2K center for big data in translational genomics
Journal of the American Medical Informatics Association 2015cited by 36position: middledoi
Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells
Stem Cell Reports 2014cited by 88position: middledoi
Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks
Nature Protocols 2012cited by 12,857position: lastdoi
Differential analysis of gene regulation at transcript resolution with RNA-seq
Nature Biotechnology 2012cited by 3,726position: lastdoi
SHAPE–Seq: High‐Throughput RNA Structure Analysis
Current Protocols in Chemical Biology 2012cited by 84position: middledoi

Grants

CAREER: Comparison and Annotation of Multiple Whole Genomes
NSF0347992$400,0002004–2010PIRePORTER

Frequent collaborators

A. Sina Booeshaghi · University of California, Berkeley4 papers (2021–2025)Kristján Eldjárn Hjörleifsson · California Institute of Technology3 papers (2021–2025)Delaney K. Sullivan · California Institute of Technology3 papers (2024–2025)Harold Pimentel · University of California, Los Angeles3 papers (2012–2024)Cole Trapnell · University of Washington3 papers (2012–2012)Páll Melsted · deCODE Genetics (Iceland)3 papers (2021–2025)David J. Anderson · California Institute of Technology2 papers (2019–2021)Lambda Moses · California Institute of Technology2 papers (2024–2025)Laura Luebbert · California Institute of Technology2 papers (2024–2025)Jase Gehring · University of Washington2 papers (2021–2021)Fan Gao · University of Alabama at Birmingham2 papers (2021–2021)Zizhen Yao · Allen Institute for Brain Science2 papers (2019–2021)Nicolas Bray · University of California, Berkeley2 papers (2017–2024)Loyal A. Goff · Johns Hopkins University2 papers (2012–2012)B Wold · California Institute of Technology2 papers (2015–2025)Kimberly A. Smith · Allen Institute for Brain Science2 papers (2019–2021)Kyung Hoi Min · Ginkgo Bioworks, Inc. (United States)2 papers (2021–2024)Hongkui Zeng · Allen Institute for Brain Science2 papers (2019–2021)Lynn Yi · California Institute of Technology2 papers (2017–2019)Bosiljka Tasic · Allen Institute for Brain Science2 papers (2019–2021)