Area of research
Genetics · Cognitive Neuroscience
Research interest
Research interests include Neuroscience, LRRK2, Dopamine, Striatum, Fragile X syndrome, and Synaptic plasticity.
Altered striatal actin dynamics drives behavioral inflexibility in a mouse model of fragile X syndrome
Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice
Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling
Deletion of Fmr1 in parvalbumin-expressing neurons results in dysregulated translation and selective behavioral deficits associated with fragile X syndrome
Correction of eIF2-dependent defects in brain protein synthesis, synaptic plasticity, and memory in mouse models of Alzheimer’s disease
Cell-type-specific disruption of PERK-eIF2α signaling in dopaminergic neurons alters motor and cognitive function
Reciprocal control of translation and transcription in autism spectrum disorder
l-DOPA promotes striatal dopamine release through D1 receptors and reversal of dopamine transporter
Cell-type-specific drug-inducible protein synthesis inhibition demonstrates that memory consolidation requires rapid neuronal translation
UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function
Leucine‐rich repeat kinase 2 (<scp>LRRK</scp>2) inhibitors differentially modulate glutamate release and Serine935 <scp>LRRK</scp>2 phosphorylation in striatal and cerebrocortical synaptosomes
Inositol polyphosphate multikinase mediates extinction of fear memory
Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model
Reducing eIF4E-eIF4G interactions restores the balance between protein synthesis and actin dynamics in fragile X syndrome model mice
Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice
Protein Kinase C β: a New Target Therapy to Prevent the Long-Term Atypical Antipsychotic-Induced Weight Gain
Genetic and pharmacological evidence that endogenous nociceptin/orphanin FQ contributes to dopamine cell loss in Parkinson's disease
d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain
LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex
Genetic and pharmacological evidence that G2019S LRRK2 confers a hyperkinetic phenotype, resistant to motor decline associated with aging
Lipid nanocarriers containing a levodopa prodrug with potential antiparkinsonian activity
Cognitive Impairment and Dentate Gyrus Synaptic Dysfunction in Experimental Parkinsonism