Area of research
Molecular Biology · Immunology and Allergy
Research interest
Research interests include Protein Structure and Dynamics, Chemical Synthesis and Analysis, RNA and protein synthesis mechanisms, and Lipid Membrane Structure and Behavior.
De novo design of porphyrin-containing proteins as efficient and stereoselective catalysts
Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation
Rapid clearance of achiral small-molecule drugs using de novo-designed proteins and their cyclic and mirror-image variants
High-throughput discovery of fluoroprobes that recognize amyloid fibril polymorphs
ProBASS—a language model with sequence and structural features for predicting the effect of mutations on binding affinity
Patterning and folding of intestinal villi by active mesenchymal dewetting
De novo design of drug-binding proteins with predictable binding energy and specificity
De novo-designed transmembrane proteins bind and regulate a cytokine receptor
IL-13 and IL-17A activate β1 integrin through an NF-kB/Rho kinase/PIP5K1γ pathway to enhance force transmission in airway smooth muscle
Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats
Stacked binding of a PET ligand to Alzheimer’s tau paired helical filaments
A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi
Transient water wires mediate selective proton transport in designed channel proteins
Soluble TREM2 inhibits secondary nucleation of Aβ fibrillization and enhances cellular uptake of fibrillar Aβ
Brilacidin, a COVID‐19 drug candidate, demonstrates broad‐spectrum antiviral activity against human coronaviruses OC43, 229E, and NL63 through targeting both the virus and the host cell
SARS-CoV-2 Envelope Protein Forms Clustered Pentamers in Lipid Bilayers
The CD3ζ adaptor structure determines functional differences between human and mouse CD16 Fc receptor signaling
Aβ and Tau Prions Causing Alzheimer’s Disease
Multiscale Simulation of an Influenza A M2 Channel Mutant Reveals Key Features of Its Markedly Different Proton Transport Behavior
De novo metalloprotein design
Constructing ion channels from water-soluble α-helical barrels
Inclusion of the C-Terminal Domain in the β-Sheet Core of Heparin-Fibrillized Three-Repeat Tau Protein Revealed by Solid-State Nuclear Magnetic Resonance Spectroscopy
Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity
<i>De novo</i>protein design, a retrospective
A defined structural unit enables de novo design of small-molecule–binding proteins
Deep mutational scanning reveals the structural basis for α-synuclein activity
Allosteric cooperation in a de novo-designed two-domain protein
Platform to Discover Protease-Activated Antibiotics and Application to Siderophore–Antibiotic Conjugates
<i>De Novo</i> Design, Solution Characterization, and Crystallographic Structure of an Abiological Mn–Porphyrin-Binding Protein Capable of Stabilizing a Mn(V) Species
X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance
Collaborative Research: De Novo Protein Constructs for Photosynthetic Energy Transduction
NSF/MCB-BSF: De novo design of minimalistic light-switchable protein binding domains
Collaborative Research: De Novo Protein Constructs for Photosynthetic Energy Transduction
Collaborative Research: De novo Protein Constructs for Photosynthetic Energy Transduction
Collaborative Research: De novo Protein Constructs for Photosynthetic Energy Transduction
Protein Mimetics Based on Beta Amino Acids
Libraries of Template-Constrained Cyclic Peptides