Area of research
Surgery · Radiology, Nuclear Medicine and Imaging
Research interest
Research topics from publications: A viscosity-activable nano-micelle with aggregation-induced emission for boosting NIR-II fluorescence imaging-guided synergetic photodynamic/photothermal therapy of breast cancer. Representative work: In view of the fast-growing achievements of cancer phototheranostics, the exploration of advanced materials shows inexhaustible and vigorous vitality. To overcome those limitations of existing materials, such as aggregation-caused fluorescence quenching, inferior selectivity, and high O 2 -dependence, the utilization of specific activatable agents with aggregation-induced emission (AIE) features is highly desirable yet remains challenging. Herein, we have designed an organic small-molecule microenvironment activated AIE agent, namely DPXBI. After encapsulation into amphiphilic DSPE-PEG-RGD through self-assembly, the biocompatibility, water solubility, targeting effect, and circulation time i