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Molecular Biology · Genetics
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Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer
Engineered prime editors with minimal genomic errors
Engineered prime editors with minimal genomic errors
RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination
Single-cell nascent RNA sequencing unveils coordinated global transcription
Single-cell nascent RNA sequencing unveils coordinated global transcription.
Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing.
Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer
Oncogenic <i>CDK13</i> mutations impede nuclear RNA surveillance
Oncogenic <i>CDK13</i> mutations impede nuclear RNA surveillance.
Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases
Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases
Single-cell nascent RNA sequencing using click-chemistry unveils coordinated transcription
RNA in formation and regulation of transcriptional condensates.
RNA in formation and regulation of transcriptional condensates
RNA-Mediated Feedback Control of Transcriptional Condensates
Partitioning of cancer therapeutics in nuclear condensates
Partitioning of cancer therapeutics in nuclear condensates.
Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons
Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
Enhancer Features that Drive Formation of Transcriptional Condensates
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia
Gain-of-function mutation of microRNA-140 in human skeletal dysplasia.
Sequestration of microRNA-mediated target repression by the Ago2-associated RNA-binding protein FAM120A.
Networks of enhancers and microRNAs drive variation in cell states
Coactivator condensation at super-enhancers links phase separation and gene control
CDK12 regulates DNA repair genes by suppressing intronic polyadenylation
Transcriptional Pause Sites Delineate Stable Nucleosome-Associated Premature Polyadenylation Suppressed by U1 snRNP
Mapping a functional cancer genome atlas of tumor suppressors in mouse liver using AAV-CRISPR–mediated direct in vivo screening