Area of research
Structural Biology · Molecular Biology
Research interest
Research interests include Biology, Cell biology, Proteasome, Protein subunit, Biophysics, and Ubiquitin.
<i>Magellon</i> – an extensible platform for cryo-EM data visualization, management and processing
CryoSift - An accessible and automated CNN-driven tool for cryo-EM 2D class selection
<i>CryoSift</i> : an accessible and automated CNN-driven tool for cryo-EM 2D class selection
Community recommendations on cryoEM data archiving and validation
Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target
DELE1 oligomerization promotes integrated stress response activation
The N1 domain of the peroxisomal AAA-ATPase Pex6 is required for Pex15 binding and proper assembly with Pex1
Structure of the hepatitis C virus E1E2 glycoprotein complex
Coupling of distant ATPase domains in the circadian clock protein KaiC
Sub-2 Angstrom resolution structure determination using single-particle cryo-EM at 200 keV
Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing
High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM
Current outcomes when optimizing ‘standard’ sample preparation for single‐particle cryo‐EM
Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation
Substrate-engaged 26 <i>S</i> proteasome structures reveal mechanisms for ATP-hydrolysis–driven translocation
Cryo-electron tomography reveals that dynactin recruits a team of dyneins for processive motility
A Multi-model Approach to Assessing Local and Global Cryo-EM Map Quality
The peroxisomal AAA-ATPase Pex1/Pex6 unfolds substrates by processive threading
Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex
Cas1 and the Csy complex are opposing regulators of Cas2/3 nuclease activity
Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition
Structural organization of the dynein–dynactin complex bound to microtubules
Protein domain mapping by internal labeling and single particle electron microscopy
High-Resolution Microtubule Structures Reveal the Structural Transitions in αβ-Tubulin upon GTP Hydrolysis
Characterization of virus-like particles in GARDASIL® by cryo transmission electron microscopy
The proteasome under the microscope: the regulatory particle in focus
Complete subunit architecture of the proteasome regulatory particle
Molecular architecture of human polycomb repressive complex 2
Go hybrid: EM, crystallography, and beyond