Area of research
Hepatology · Epidemiology
Research interest
There are specific research projects that can only be conducted at Hiroshima University, including the use of the "human hepatocyte chimeric mouse," which is a chimeric mouse model in which >70-90% of the mouse liver is replaced with normal human hepatocytes and can be infected persistently with hepatitis B and C virus. This mouse model enables us to conduct a wide range of experiments to elucidate the mechanism of viral infection. We can easily manage this technology, making us an attractive collaborator for many hepatitis researchers worldwide.
Targeting the liver clock improves fibrosis by restoring TGF-β signaling
An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection
Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture
Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and <scp>TGFβ</scp> activity in liver fibrosis
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma
Genomic and Transcriptomic Profiling of Combined Hepatocellular and Intrahepatic Cholangiocarcinoma Reveals Distinct Molecular Subtypes
HCV-Induced Epigenetic Changes Associated With Liver Cancer Risk Persist After Sustained Virologic Response
Combined Analysis of Metabolomes, Proteomes, and Transcriptomes of Hepatitis C Virus–Infected Cells and Liver to Identify Pathways Associated With Disease Development
miR-135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis
Individual patient data meta-analysis of controlled attenuation parameter (CAP) technology for assessing steatosis
Type 2 diabetes mellitus is associated with the fibrosis severity in patients with nonalcoholic fatty liver disease in a large retrospective cohort of Japanese patients
Identification of a Functional Variant in the MICA Promoter Which Regulates MICA Expression and Increases HCV-Related Hepatocellular Carcinoma Risk
Identification of the Niemann-Pick C1–like 1 cholesterol absorption receptor as a new hepatitis C virus entry factor