Area of research
Molecular Biology · Materials Chemistry
Research interest
Research interests include Protein Degradation and Inhibitors, Ubiquitin and proteasome pathways, Cell death mechanisms and regulation, and Enzyme Structure and Function.
Lisaftoclax (APG-2575) Is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy
Targeted disruption of pi–pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity
Heteromeric three-stranded coiled coils designed using a Pb(ii)(Cys)3 template mediated strategy
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins
Structure of the zinc-finger antiviral protein in complex with RNA reveals a mechanism for selective targeting of CG-rich viral sequences
Targeted Degradation of BET Proteins in Triple-Negative Breast Cancer
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)–Mixed Lineage Leukemia (MLL) Protein–Protein Interaction
D3R grand challenge 2015: Evaluation of protein–ligand pose and affinity predictions
KRAS Engages AGO2 to Enhance Cellular Transformation
Engineering a Therapeutic Lectin by Uncoupling Mitogenicity from Antiviral Activity
Structural and Functional Characterization of a Cytochrome P450 2B4 F429H Mutant with an Axial Thiolate–Histidine Hydrogen Bond
Ordering a Dynamic Protein Via a Small-Molecule Stabilizer