Area of research
Molecular Biology · Pulmonary and Respiratory Medicine
Research interest
Research interests include PI3K/AKT/mTOR signaling in cancer, Protein Degradation and Inhibitors, Advanced Breast Cancer Therapies, and Protein Kinase Regulation and GTPase Signaling.
Binding of the SARS-CoV-2 envelope E protein to human BRD4 is essential for infection
COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges
Combinatorial Approach to Improve Cancer Immunotherapy: Rational Drug Design Strategy to Simultaneously Hit Multiple Targets to Kill Tumor Cells and to Activate the Immune System
Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication
Dual-activity PI3K–BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis
The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity
Vascular remodeling underlies rebleeding in hemophilic arthropathy
A Macrophage-Dominant PI3K Isoform Controls Hypoxia-Induced HIF1α and HIF2α Stability and Tumor Growth, Angiogenesis, and Metastasis
Rac2 Controls Tumor Growth, Metastasis and M1-M2 Macrophage Differentiation In Vivo
Synthesis and Cancer Stem Cell-Based Activity of Substituted 5-Morpholino-7<i>H</i>-thieno[3,2-<i>b</i>]pyran-7-ones Designed as Next Generation PI3K Inhibitors
Pediatric Phase II Trials of Poly-ICLC in the Management of Newly Diagnosed and Recurrent Brain Tumors
Phase I pharmacokinetic and pharmacodynamic study of the pan-PI3K/mTORC vascular targeted pro-drug SF1126 in patients with advanced solid tumours and B-cell malignancies
Distinct roles for fibroblast growth factor signaling in cerebellar development and medulloblastoma