Arnon Lavie

Novel Insights on the Use of L-Asparaginase as an Efficient and Safe Anti-Cancer Therapy

<i>In vivo</i> stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia

pH-Dependent Mechanisms of Influenza Infection Mediated by Hemagglutinin

The spleen as a sanctuary site for residual leukemic cells following ABT-199 monotherapy in ETP-ALL

Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor

Metabolic Modifier Screen Reveals Secondary Targets of Protein Kinase Inhibitors within Nucleotide Metabolism

Identifying small molecule probes of ENTPD5 through high throughput screening

NMR-based metabolite studies with 15N amino acids

Identification of a pH sensor in Influenza hemagglutinin using X-ray crystallography

A Novel <scp>l</scp> -Asparaginase with low <scp>l</scp> -Glutaminase Coactivity Is Highly Efficacious against Both T- and B-cell Acute Lymphoblastic Leukemias <i>In Vivo</i>

Identification of a Unique Inhibitor-Binding Site on Choline Kinase α

Discovery of human-like L-asparaginases with potential clinical use by directed evolution

The differential ability of asparagine and glutamine in promoting the closed/active enzyme conformation rationalizes the Wolinella succinogenes L-asparaginase substrate specificity

Design and Characterization of Erwinia Chrysanthemi l-Asparaginase Variants with Diminished l-Glutaminase Activity

[¹⁸F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity

Structural Insight into Substrate Selectivity of <i>Erwinia chrysanthemi</i> <scp>l</scp>-Asparaginase

Experimental Data in Support of a Direct Displacement Mechanism for Type I/II l-Asparaginases

Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins

Identification and Structural Analysis of an l-Asparaginase Enzyme from Guinea Pig with Putative Tumor Cell Killing Properties

Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication

Elucidation of the Specific Function of the Conserved Threonine Triad Responsible for Human l-Asparaginase Autocleavage and Substrate Hydrolysis

Structural and Kinetic Characterization of Guinea Pig <scp>l</scp>-Asparaginase Type III

Structure-Guided Development of Deoxycytidine Kinase Inhibitors with Nanomolar Affinity and Improved Metabolic Stability

Discovery of Selective Inhibitors of the Clostridium difficile Dehydroquinate Dehydratase

Free Glycine Accelerates the Autoproteolytic Activation of Human Asparaginase

The Engineered Thymidylate Kinase (TMPK)/AZT Enzyme-Prodrug Axis Offers Efficient Bystander Cell Killing for Suicide Gene Therapy of Cancer

Development of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission Tomography

Structures of Apo and Product-Bound Human <scp>l</scp>-Asparaginase: Insights into the Mechanism of Autoproteolysis and Substrate Hydrolysis

Balance of human choline kinase isoforms is critical for cell cycle regulation

Cell Fate Control Gene Therapy Based on Engineered Variants of Human Deoxycytidine Kinase