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Mandy J. McGeachy

Broad Institute · US
Area of research
Immunology
Research interest
Research interests include Psoriasis: Treatment and Pathogenesis, T-cell and B-cell Immunology, Immunodeficiency and Autoimmune Disorders, and Immune Cell Function and Interaction.
h-index
36
citations
11,532
works
89
NIH funding
primary concept
email

Recent publications

Granzyme K activates the entire complement cascade
Nature 2025cited by 97position: middledoi
Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis
Science Translational Medicine 2024cited by 61position: middledoi
Clonal associations between lymphocyte subsets and functional states in rheumatoid arthritis synovium
Nature Communications 2024cited by 47position: middledoi
Longitudinal patterns and predictors of response to standard-of-care therapy in lupus nephritis: data from the Accelerating Medicines Partnership Lupus Network
Arthritis Research & Therapy 2024cited by 23position: middledoi
Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis
Nature Communications 2024cited by 15position: middledoi
Automated multi-scale computational pathotyping (AMSCP) of inflamed synovial tissue
Nature Communications 2024cited by 7position: middledoi
Changing behind the scenes.
2024cited by 0position: contributordoi
Mapping the dynamic genetic regulatory architecture of HLA genes at single-cell resolution
Nature Genetics 2023cited by 41position: middledoi
IκBζ is an essential mediator of immunity to oropharyngeal candidiasis
Cell Host & Microbe 2023cited by 21position: middledoi
Human IL-17A protein production is controlled through a PIP5K1α-dependent translational checkpoint.
2023cited by 4position: contributordoi
Local IL-23 is required for proliferation and retention of skin-resident memory T <sub>H</sub> 17 cells
Science Immunology 2022cited by 107position: middledoi
High incidence of proliferative and membranous nephritis in SLE patients with low proteinuria in the Accelerating Medicines Partnership
Lara D. Veeken 2022cited by 29position: middledoi
Matrix reboot: IL-17 signals CAFs to create a second tumor T cell checkpoint.
2022cited by 0position: contributordoi
IL-17-dependent fibroblastic reticular cell training boosts tissue protective mucosal immunity through IL-10-producing B cells.
2021cited by 11position: contributordoi
Notch signalling drives synovial fibroblast identity and arthritis pathology
Nature 2020cited by 524position: middledoi
The IL-17 Family of Cytokines in Health and Disease
Immunity 2019cited by 1,404position: firstdoi
IL-17 receptor-based signaling and implications for disease.
2019cited by 423position: contributordoi
IL-17 metabolically reprograms activated fibroblastic reticular cells for proliferation and survival.
2019cited by 85position: contributordoi
Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue
Arthritis Research & Therapy 2018cited by 130position: middledoi
The far-reaching scope of neuroinflammation after traumatic brain injury
Nature Reviews Neurology 2017cited by 1,154position: middledoi
Oral epithelial cells orchestrate innate type 17 responses to <i>Candida albicans</i> through the virulence factor candidalysin
Science Immunology 2017cited by 204position: middledoi
Persistence of Disease‐Associated Anti–Citrullinated Protein Antibody–Expressing Memory B Cells in Rheumatoid Arthritis in Clinical Remission
Arthritis & Rheumatology 2017cited by 39position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Sarah L. Gaffen · University of Pittsburgh3 papers (2017–2023) · 3 papers (2019–2023)Sarah L. Gaffen · University of Pittsburgh2 papers (2019–2023)Saikat Majumder · Bose Institute2 papers (2021–2023) · 2 papers (2017–2023)Amanda C. Poholek · University of Pittsburgh2 papers (2019–2023)Toshiro Hirai · Institut de Recherche Vaccinale1 papers (2022–2022)Jemima Ho · King's College London1 papers (2017–2017)Casey T. Weaver · University of Alabama at Birmingham1 papers (2022–2022) · 1 papers (2017–2017)Jeffrey D. Greenberg · Bentley University1 papers (2017–2017)David L. Moyes · King's College London1 papers (2017–2017)Partha S. Biswas · Hospital for Special Surgery1 papers (2017–2017)Larry Kane · Rockefeller University1 papers (2017–2017)Gregg J. Silverman · New York University1 papers (2017–2017)Jonathan P. Richardson · King's College London1 papers (2017–2017)Daniel H. Kaplan · University of Pittsburgh1 papers (2022–2022)Daniella M. Schwartz · Virginia Commonwealth University1 papers (2023–2023) · 1 papers (2023–2023)Kritika Ramani · University of Pittsburgh Medical Center1 papers (2017–2017)