Area of research
Pulmonary and Respiratory Medicine · Cancer Research
Research interest
Research interests include Protease and Inhibitor Mechanisms, Neonatal Respiratory Health Research, Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis, and Cell Adhesion Molecules Research.
A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis
Human distal airways contain a multipotent secretory cell that can regenerate alveoli
Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells
Alveolar regeneration through a Krt8+ transitional stem cell state that persists in human lung fibrosis
Collagen promotes anti-PD-1/PD-L1 resistance in cancer through LAIR1-dependent CD8+ T cell exhaustion
Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration
Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung
Reversal of TGFβ1-Driven Profibrotic State in Patients with Pulmonary Fibrosis
Yap/Taz regulate alveolar regeneration and resolution of lung inflammation
Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis
Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung
Extracellular matrix in lung development, homeostasis and disease
Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype
Local lung hypoxia determines epithelial fate decisions during alveolar regeneration
Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis
Hypoxia-Inducible Factor 1α Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury
Persistent Pathology in Influenza-Infected Mouse Lungs
Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function
Innate Antiviral Host Defense Attenuates TGF-β Function through IRF3-Mediated Suppression of Smad Signaling
Urokinase-type Plasminogen Activator Receptor (uPAR) Ligation Induces a Raft-localized Integrin Signaling Switch That Mediates the Hypermotile Phenotype of Fibrotic Fibroblasts
Future Directions in Idiopathic Pulmonary Fibrosis Research. An NHLBI Workshop Report
Cathepsin F mutations cause Type B Kufs disease, an adult-onset neuronal ceroid lipofuscinosis
BPIFB1 Is a Lung-Specific Autoantigen Associated with Interstitial Lung Disease
Molecular Determinants of Lung Development
Activated Alveolar Epithelial Cells Initiate Fibrosis through Secretion of Mesenchymal Proteins
Inhibition of Epithelial-to-Mesenchymal Transition and Pulmonary Fibrosis by Methacycline
Cell Therapy for Lung Diseases. Report from an NIH–NHLBI Workshop, November 13–14, 2012
Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors
Regenerative activity of the lung after epithelial injury