Area of research
Molecular Biology · Endocrine and Autonomic Systems
Research interest
Research interests include Wnt/β-catenin signaling in development and cancer, Cancer-related gene regulation, Circadian rhythm and melatonin, and RNA Research and Splicing.
PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period
A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models
PERIOD phosphorylation leads to feedback inhibition of CK1 activity to control circadian period
A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion
Casein kinase 1 dynamics underlie substrate selectivity and the PER2 circadian phosphoswitch
Wnt Signaling and Drug Resistance in Cancer
PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers
CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds
Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2
Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis
<i>TP53</i> intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion
Disulfide Bond Requirements for Active Wnt Ligands
Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity
Updating the Wnt pathways
Unwinding the Wnt action of casein kinase 1
Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling