Area of research
Molecular Biology · Oncology
Research interest
Research interests include Wnt signaling pathway, Biology, Cancer research, Cell biology, PI3K/AKT/mTOR pathway, and Pancreatic cancer.
A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models
PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers
USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds
Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis
<i>TP53</i> intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome
Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts
Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
VS-5584, a Novel and Highly Selective PI3K/mTOR Kinase Inhibitor for the Treatment of Cancer