Area of research
Molecular Biology · Immunology
Research interest
Research interests include DNA Repair Mechanisms, Epigenetics and DNA Methylation, T-cell and B-cell Immunology, and Immune Cell Function and Interaction.
Biomarkers of response to immunotherapy in pancreatic ductal adenocarcinoma (PDAC) with homologous recombination deficiency (HRD).
Loss of p53 enhances LMO2 induced transdifferentiation of B-cells to T-cell acute lymphoblastic leukemia
PRAME induces genomic instability in uveal melanoma
Oxidized mC modulates synthetic lethality to PARP inhibitors for the treatment of leukemia
Fanconi anemia associated protein 20 (FAAP20) plays an essential role in homology-directed repair of DNA double-strand breaks
Endocrine resistance and breast cancer plasticity are controlled by CoREST
LMO2 expression is frequent in T-lymphoblastic leukemia and correlates with survival, regardless of T-cell stage
The Polycomb protein RING1B enables estrogen-mediated gene expression by promoting enhancer–promoter interaction and R-loop formation
Kaposi’s sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis
Estrogen induces dynamic ERα and RING1B recruitment to control gene and enhancer activities in luminal breast cancer
The uracil-DNA glycosylase UNG protects the fitness of normal and cancer B cells expressing AID
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL
Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL
PRMT5 Regulates DNA Repair by Controlling the Alternative Splicing of Histone-Modifying Enzymes
A licensing step links AID to transcription elongation for mutagenesis in B cells
Epstein-Barr virus-positive follicular lymphoma
The microRNA-23b/-27b cluster suppresses prostate cancer metastasis via Huntingtin-interacting protein 1-related
Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma
UNG protects B cells from AID-induced telomere loss
Class-Switch Recombination in the Absence of the IgH 3′ Regulatory Region
Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma
Activation induced deaminase C-terminal domain links DNA breaks to end protection and repair during class switch recombination
Alternative End-Joining and Classical Nonhomologous End-Joining Pathways Repair Different Types of Double-Strand Breaks during Class-Switch Recombination
Severe Heat Shock Induces Nucleolar Accumulation of mRNAs in Trypanosoma cruzi