Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Protein Kinase Regulation and GTPase Signaling, Ubiquitin and proteasome pathways, Protein Degradation and Inhibitors, and Microtubule and mitosis dynamics.
Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor
Un-LOK-ing a New Approach for Conformational Selective Targeting of STK10 (LOK)
Repurposing of the RIPK1 selective benzo[1,4]oxazepin-4-one scaffold for the development of a type-III LIMK1/2 inhibitor
Development of Potent Dual BET/HDAC Inhibitors via Pharmacophore Merging and Structure-Guided Optimization
Probing the Protein Kinases′ Cysteinome by Covalent Fragments
Untersuchung der Adressierbarkeit des Cysteinoms der Proteinkinasen durch Kovalente Fragmente
Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2
Deep Annotation of Donated Chemical Probes (DCP) in Organotypic Human Liver Cultures and Patient-Derived Organoids from Tumor and Normal Colorectum
Development of potent dual BET/HDAC inhibitors <i>via</i> pharmacophore merging and structure-guided optimization
Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes
Novel, highly potent PROTACs targeting AURORA-A kinase
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins
Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2
Controlling the Covalent Reactivity of a Kinase Inhibitor with Light
Controlling the Covalent Reactivity of a Kinase Inhibitor with Light
Characterization of a dual <scp>BET</scp>/<scp>HDAC</scp> inhibitor for treatment of pancreatic ductal adenocarcinoma
Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib
Selective targeting of the αC and DFG-out pocket in p38 MAPK
Binding Kinetics Survey of the Drugged Kinome
NVP‐BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement