Area of research
Biomedical Engineering · Immunology
Research interest
Research interests include Bone Tissue Engineering Materials, Cardiac Valve Diseases and Treatments, Aortic Disease and Treatment Approaches, and T-cell and B-cell Immunology.
Click. Screen. Degrade. A Miniaturized D2B Workflow for Rapid PROTAC Discovery
Type II kinase inhibitors that target Parkinson’s disease–associated LRRK2
Protein–ligand data at scale to support machine learning
Covalent Targeting Leads to the Development of a LIMK1 Isoform-Selective Inhibitor
Repurposing of the RIPK1-Selective Benzo[1,4]oxazepin-4-one Scaffold for the Development of a Type III LIMK1/2 Inhibitor
Un-LOK-ing a New Approach for Conformational Selective Targeting of STK10 (LOK)
Repurposing of the RIPK1 selective benzo[1,4]oxazepin-4-one scaffold for the development of a type-III LIMK1/2 inhibitor
Click. Screen. Degrade. A Miniaturized D2B Workflow for rapid PROTAC Discovery
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets
Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
Synthesis of Pyrazole-Based Macrocycles Leads to a Highly Selective Inhibitor for MST3
Design and Synthesis of Pyrazole-Based Macrocyclic Kinase Inhibitors Targeting BMPR2
Targeting LC3/GABARAP for degrader development and autophagy modulation
Synthesis of pyrazole-based macrocycles leads to a highly selective inhibitor for MST3
Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes
Discovery of 3-Amino-1H-pyrazole-Based Kinase Inhibitors to Illuminate the Understudied PCTAIRE Family
Synthetic Opportunities and Challenges for Macrocyclic Kinase Inhibitors
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement