Area of research
Physiology · Immunology
Research interest
Research interests include Telomeres, Telomerase, and Senescence, Adipose Tissue and Metabolism, T-cell and B-cell Immunology, and Circadian rhythm and melatonin.
Telomere uncapping and vascular aging
Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress
Characterization of cognitive impairments and neurotransmitter changes in a novel transgenic mouse lacking Slc10a4
Cellular and molecular biology of aging endothelial cells
Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation
Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness
Age-related arterial telomere uncapping and senescence is greater in women compared with men
The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction
Role of arterial telomere dysfunction in hypertension
Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries
Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries
TNF-α impairs endothelial function in adipose tissue resistance arteries of mice with diet-induced obesity
Equipment for Physiology Teaching
Incorporation of Modern Evolutionary Research Methods into an Undergraduate Laboratory
Photochemical Dynamics in Semiconductor Colloids
Modernization of Optics Experiments in Advanced Undergraduate Labs
Supercomputer Initiation: Numeric Simulation of Stress Waves in Solids