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C. Dirk Keene

Seattle Pacific University · US
Area of research
Physiology · Neurology
Research interest
Research interests include Alzheimer's disease research and treatments, Dementia and Cognitive Impairment Research, Neuroinflammation and Neurodegeneration Mechanisms, and Traumatic Brain Injury Research.
h-index
84
citations
41,131
works
540
NIH funding
primary concept
Medicine
email

Recent publications

Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing
Nature Communications 2025cited by 13position: middledoi
Cross-species consensus atlas of the primate basal ganglia
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 8position: middledoi
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
Neuron 2025cited by 8position: middledoi
A cross-species spatial transcriptomic atlas of the human and non-human primate basal ganglia
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 7position: middledoi
Beyond mild, moderate, and severe traumatic brain injury: modelling severity from clinical, neuroimaging, and blood-based indicators
EBioMedicine 2025cited by 4position: middledoi
Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer’s disease
Brain 2025cited by 3position: middledoi
Genome‐wide association studies of TDP‐43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B
Alzheimer s & Dementia 2025cited by 2position: middledoi
Chronic traumatic encephalopathy neuropathologic change in the Late Effects of Traumatic Brain Injury project: Findings in a community autopsy cohort
Journal of Neuropathology & Experimental Neurology 2025cited by 1position: middledoi
Single-cell multiomic human brain atlas reveals regulatory drivers of cortical regionality
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 1position: middledoi
Epigenomic profile of GBA1 in Parkinson's disease
Parkinsonism & Related Disorders 2025cited by 1position: middledoi
Single Cell Landscape of Sex-specific Drivers of Alzheimer’s Disease
bioRxiv (Cold Spring Harbor Laboratory) 2025cited by 0position: middledoi
Presence of Alzheimer's disease variants in circular RNA of <i>PSEN1</i> and <i>PSEN2</i>
Journal of Alzheimer s Disease 2025cited by 0position: middledoi
Integrated platform for multiscale molecular imaging and phenotyping of the human brain
Science 2024cited by 51position: middledoi
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer’s disease pathology
Neuron 2024cited by 41position: middledoi
Performance of the IMPACT and CRASH prognostic models for traumatic brain injury in a contemporary multicenter cohort: a TRACK-TBI study
Journal of neurosurgery 2024cited by 36position: middledoi
Mapping human tissues with highly multiplexed RNA in situ hybridization
Nature Communications 2024cited by 32position: middledoi
SEA-AD is a multimodal cellular atlas and resource for Alzheimer’s disease
Nature Aging 2024cited by 24position: middledoi
Biomarker‐Based Approach to α‐Synucleinopathies: Lessons from Neuropathology
Movement Disorders 2024cited by 17position: middledoi
pTau‐associated gene expression signatures in the middle temporal gyrus
Alzheimer s & Dementia 2024cited by 0position: middledoi
A systems‐biology approach to identify candidate genes associated with composite brain pathology scores in the Adult Changes of Thought (ACT) and the Religious Orders Study and Memory and Aging Project (ROSMAP) autopsy cohorts
Alzheimer s & Dementia 2024cited by 0position: middledoi
Transcriptomic diversity of cell types across the adult human brain
Science 2023cited by 724position: middledoi
Comparative transcriptomics reveals human-specific cortical features
Science 2023cited by 191position: middledoi
Transcriptomic cytoarchitecture reveals principles of human neocortex organization
Science 2023cited by 190position: middledoi
A comparative atlas of single-cell chromatin accessibility in the human brain
Science 2023cited by 152position: middledoi
Single-cell DNA methylation and 3D genome architecture in the human brain
Science 2023cited by 151position: middledoi
Clonal hematopoiesis is associated with protection from Alzheimer’s disease
Nature Medicine 2023cited by 141position: middledoi
Signature morphoelectric properties of diverse GABAergic interneurons in the human neocortex
Science 2023cited by 118position: middledoi
Morphoelectric and transcriptomic divergence of the layer 1 interneuron repertoire in human versus mouse neocortex
Science 2023cited by 80position: middledoi
Interindividual variation in human cortical cell type abundance and expression
Science 2023cited by 72position: middledoi
Integrated multimodal cell atlas of Alzheimer’s disease
Research Square 2023cited by 63position: middledoi

Grants

Neural mechanisms of sleep loss in Mexican cavefish
NSF1656574$333,0002017–2021PIRePORTER
Localization of dopamine function in gustatory memory
NSF1551136$397,8962015–2019PIRePORTER
Localization of dopamine function in gustatory memory
NSF1457062$397,8962015–2015PIRePORTER
Collaborative Research: Coupled Ocean-Atmosphere Recycling of Refractory Dissolved Organic Carbon in Seawater
NSF1536674$225,8852015–2018PIRePORTER
Regulation of sleep in the Mexican cavefish
NSF1601004$133,7782015–2017PIRePORTER
Collaborative Research: Emergency Funding for Repair of the Bermuda Institute of Ocean Sciences Tudor Hill Marine Atmospheric Observatory
NSF1536670$89,4282015–2016PIRePORTER
Collaborative Research: Measurements of Selected Combustion Emissions in Nepal and Bhutan Integrated with Source Apportionment and Chemical Transport Modeling for South Asia
NSF1355551$107,9912014–2017PIRePORTER
Regulation of sleep in the Mexican cavefish
NSF1257062$347,0412013–2015PIRePORTER
Collaborative Research: Production Fluxes and Physicochemical Properties of Nascent Marine Aerosols: Implications for the Atmosphere and Upper Ocean.
NSF1129836$171,0902012–2015PIRePORTER
Collaborative Research: Halogen Activation and Multiphase Chemical Processing in the Continental Boundary Layer
NSF1041187$316,9132011–2014PIRePORTER
Collaborative Research: Reactive Halogens in the Marine Boundary Layer (RHaMBLe) Overlying the Eastern Tropical North Atlantic Ocean
NSF0646854$265,7732007–2009PIRePORTER
Collaborative Research: The Processing and Radiative Properties of Aerosols over the Western North Atlantic Ocean at Bermuda
NSF0541570$1,194,3002006–2014PIRePORTER
SGER: Parameterization of Sea-Salt Cloud Condensation Nuclei (CCN) Production for 3-D Earth System Models
NSF0638741$25,9702006–2008PIRePORTER
Collaborative Research: Photochemical Production of Radical Oxidants and Hydroperoxides from Organic Matter and Nitrate in Sea-Salt Aerosols
NSF0343146$382,3062004–2008PIRePORTER
Collaborative Research: Influences of Halogen Chemistry on Processing of North American Pollutant Outflow
NSF0401628$288,2382004–2007PIRePORTER
Collaborative Research: Multiphase Halogen Chemistry in the Atlantic Marine Boundary Layer
NSF0328342$264,1912003–2007PIRePORTER
Collaborative Research: Aerosol Acidity and Multiphase Chemical Processes in the New England Coastal Atmosphere
NSF0207786$184,9922002–2005PIRePORTER
Collaborative Research: Biomass Burning Emission Over Southern Africa
NSF0003865$222,8912000–2003PIRePORTER
Installation of Scaffolding Tower at Kosan, Korea: Aerosol Characterization Experiment (ACE)-Asia Surface Network Implementation, Operations, and Coordination
NSF0002176$89,6972000–2003PIRePORTER
Collaborative Research: The Multiphase Chemistry of Inorganic Halogens in the Marine Boundary Layer at Hawaii During Summer
NSF9902077$201,7241999–2002PIRePORTER
The pH of Sea Salt Aerosol
NSF9634129$133,0451997–2000PIRePORTER
The Chemistry of Inorganic Chlorine in the Marine Boundary Layer at Bermuda During Spring
NSF9415559$168,2671995–1998PIRePORTER

Frequent collaborators

Paul K. Crane · University of Washington11 papers (2015–2024)Ed S. Lein · Allen Institute for Brain Science11 papers (2018–2025)Rebecca D. Hodge · Allen Institute for Brain Science8 papers (2018–2025)Laura E. Gibbons · San Francisco VA Medical Center7 papers (2015–2024)Thomas J. Montine · Stanford University7 papers (2015–2025)Kristen Dams-O’Connor · University of Utah7 papers (2015–2025)Thomas D. Bird · University of Washington7 papers (2016–2022)Jeremy A. Miller · Indiana University Bloomington5 papers (2018–2024)Mariano I. Gabitto · Allen Institute for Brain Science5 papers (2022–2025)Shubhabrata Mukherjee · University of Washington5 papers (2017–2022)Caitlin S. Latimer · University of Washington4 papers (2020–2024)Kyle J. Travaglini · Allen Institute4 papers (2024–2025)Thomas J. Grabowski · University of Washington4 papers (2015–2024)Philip L. De Jager · Mayo Clinic in Florida4 papers (2017–2025)John F. Crary · Icahn School of Medicine at Mount Sinai4 papers (2015–2025)Andrew L. Ko · George Washington University4 papers (2018–2022)Daniel P. Perl · Unifor4 papers (2015–2022)Joshua A. Sonnen · Arkana Laboratories4 papers (2015–2018)Carlo Condello · University of California, San Francisco4 papers (2016–2022)Eric B. Larson · University of Washington4 papers (2015–2017)