Area of research
Molecular Biology · Neurology
Research interest
Research interests include Single-cell and spatial transcriptomics, Neuroinflammation and Neurodegeneration Mechanisms, Cell Image Analysis Techniques, and Neural dynamics and brain function.
An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal Ganglia
Single-cell Multiome Analysis of Chromatin State and Transcriptome in the Human Basal Ganglia
The Caudate Nucleus Exhibits Distinct Pathology and Cell Type-Specific Responses Across Alzheimer’s Disease
HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species
Cell type-selective AADC expression reduces motor deficits and dyskinesia in Parkinson’s disease mouse models
A Multimodal Single-Cell Epigenomic and 3D Genome Atlas of the Human Basal Ganglia
Enhancer-Based AAV Approach for Selective AADC Delivery Reduces Motor Symptoms and Dyskinesia in Parkinson’s Mouse Models
Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate Striatum
Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states
Interneuron-specific dual-AAV <i>SCN1A</i> gene replacement corrects epileptic phenotypes in mouse models of Dravet syndrome
Human BioMolecular Atlas Program (HuBMAP): 3D Human Reference Atlas construction and usage
Enhancer AAVs for targeting spinal motor neurons and descending motor pathways in rodents and macaque
Evaluating methods for the prediction of cell-type-specific enhancers in the mammalian cortex
Cross-species consensus atlas of the primate basal ganglia
Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration
A molecular cell atlas of mouse lemur, an emerging model primate
AAV delivery of full-length SYNGAP1 rescues epileptic and behavioral phenotypes in a mouse model of SYNGAP1-related disorders
A cross-species spatial transcriptomic atlas of the human and non-human primate basal ganglia
Mouse lemur cell atlas informs primate genes, physiology and disease
Technical and biological sources of noise confound multiplexed enhancer AAV screening
AAV serotype PHP.eB achieves superior neuronal transduction efficiency compared to AAV9 in pigtail macaques following intracerebroventricular administration
AAV-PHP.eB achieves superior neuronal transduction over AAV9 in pigtail macaques following intracerebroventricular administration
MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics
MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics
Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species
Single-cell multiomic human brain atlas reveals regulatory drivers of cortical regionality
HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate species
Cytosplore EvoViewer: Visual Analytics of Conserved Evolutionary Patterns in multi-species single-cell sequencing data
Enhancer-AAVs allow genetic access to oligodendrocytes and diverse populations of astrocytes across species
MerQuaCo: a computational tool for quality control in image-based spatial transcriptomics