Dhirendra K. Simanshu

Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation

Nature Communications 2025cited by 28position: lastdoi

BBO-10203 inhibits tumor growth without inducing hyperglycemia by blocking RAS-PI3Kα interaction

Science 2025cited by 24position: firstdoi

Biophysical and structural analysis of KRAS switch-II pocket inhibitors reveals allele-specific binding constraints

Journal of Biological Chemistry 2025cited by 11position: middledoi

Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin

Science 2025cited by 10position: middledoi

Structural basis for LZTR1 recognition of RAS GTPases for degradation

Science 2025cited by 8position: lastdoi

Blocking C-terminal processing of KRAS4b via a direct covalent attack on the CaaX-box cysteine

Proceedings of the National Academy of Sciences 2025cited by 5position: middledoi

Discovery of BBO-8520, a First-In-Class Direct and Covalent Dual Inhibitor of GTP-Bound (ON) and GDP-Bound (OFF) KRASG12C

Cancer Discovery 2024cited by 42position: middledoi

Functional and structural insights into RAS effector proteins

Molecular Cell 2024cited by 19position: middledoi

Consensus on the RAS dimerization hypothesis: Strong evidence for lipid-mediated clustering but not for G-domain-mediated interactions

Molecular Cell 2023cited by 53position: firstdoi

RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy

Science Advances 2023cited by 24position: middledoi

Machine learning–driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins

Proceedings of the National Academy of Sciences 2022cited by 87position: middledoi

Structure of the SHOC2–MRAS–PP1C complex provides insights into RAF activation and Noonan syndrome

Nature Structural & Molecular Biology 2022cited by 52position: lastdoi

KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation

Nature Communications 2021cited by 248position: lastdoi

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR

Cell Reports 2020cited by 69position: lastdoi

The small molecule BI-2852 induces a nonfunctional dimer of KRAS

Proceedings of the National Academy of Sciences 2020cited by 66position: middledoi

KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis

Proceedings of the National Academy of Sciences 2019cited by 129position: middledoi

RIT1 oncoproteins escape LZTR1-mediated proteolysis

Science 2019cited by 123position: middledoi

RAS Proteins and Their Regulators in Human Disease

Cell 2017cited by 1,911position: firstdoi

Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ

Proceedings of the National Academy of Sciences 2016cited by 176position: lastdoi

A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer

Molecular Cell 2014cited by 142position: middledoi

INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in <i>Arabidopsis</i>

Proceedings of the National Academy of Sciences 2012cited by 82position: middledoi

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