Area of research
Molecular Biology · Hematology
Research interest
Research interests include Protein Tyrosine Phosphatases, Protein Kinase Regulation and GTPase Signaling, RNA modifications and cancer, and Acute Myeloid Leukemia Research.
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy
Pharmacological restoration of GTP hydrolysis by mutant RAS
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
RAS-dependent RAF-MAPK hyperactivation by pathogenic RIT1 is a therapeutic target in Noonan syndrome–associated cardiac hypertrophy
Impaired Proteolysis of Noncanonical RAS Proteins Drives Clonal Hematopoietic Transformation
RIT1 oncoproteins escape LZTR1-mediated proteolysis