Area of research
Molecular Biology · Cancer Research
Research interest
Research interests include Melanoma and MAPK Pathways, Protein Kinase Regulation and GTPase Signaling, Cancer Genomics and Diagnostics, and vaccines and immunoinformatics approaches.
Pharmacological restoration of GTP hydrolysis by mutant RAS
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS
The G protein signaling regulator RGS3 enhances the GTPase activity of KRAS
Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition
An approach to suppress the evolution of resistance in BRAFV600E-mutant cancer