Area of research
Molecular Biology · Cell Biology
Research interest
Research interests include Microtubule and mitosis dynamics, Genomics and Chromatin Dynamics, Ubiquitin and proteasome pathways, and DNA Repair Mechanisms.
CTCF and R-loops are boundaries of cohesin-mediated DNA looping
Cryo-EM structure of human O-GlcNAcylation enzyme pair OGT-OGA complex
Cryo-EM structures of human p97 double hexamer capture potentiated ATPase-competent state
Prolonged activation of innate immune pathways by a polyvalent STING agonist
Author Correction: Prolonged activation of innate immune pathways by a polyvalent STING agonist
Structure of human GABAB receptor in an inactive state
Author Correction: Structure of human GABAB receptor in an inactive state
Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor–ligand complex
Structural basis of the activation of type 1 insulin-like growth factor receptor
PUMILIO hyperactivity drives premature aging of Norad-deficient mice
Mitotic regulators and the SHP2-MAPK pathway promote IR endocytosis and feedback regulation of insulin signaling
Structural basis of tubulin detyrosination by vasohibins
Structural Insight into DNA-Dependent Activation of Human Metalloprotease Spartan
Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment
Scc2 Is a Potent Activator of Cohesin’s ATPase that Promotes Loading by Binding Scc1 without Pds5
The BUB3-BUB1 Complex Promotes Telomere DNA Replication
MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion
Interaction of the Warsaw breakage syndrome DNA helicase DDX11 with the replication fork-protection factor Timeless promotes sister chromatid cohesion
Sumoylation promotes optimal APC/C activation and timely anaphase
Spindle Checkpoint Regulators in Insulin Signaling
Cyclin A Turns on Bora to Light the Path to Mitosis
Mitotic transcription and waves of gene reactivation during mitotic exit
A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling
Ska3 Phosphorylated by Cdk1 Binds Ndc80 and Recruits Ska to Kinetochores to Promote Mitotic Progression
Familial STAG2 germline mutation defines a new human cohesinopathy
Mechanistic insight into TRIP13-catalyzed Mad2 structural transition and spindle checkpoint silencing
Releasing the cohesin ring: A rigid scaffold model for opening the DNA exit gate by Pds5 and Wapl
Partner switching for Ran during the mitosis dance
Structural Basis and IP6 Requirement for Pds5-Dependent Cohesin Dynamics
Crystal structure of the cohesin loader Scc2 and insight into cohesinopathy
Connecting Interdisciplinary STEM Education and Research in HBCUs
Chemistry REU Principal Investigators' Workshop
CRIF MU: Acquisition of a Multi-User GC-MS Instrument
MRI: Acquisition of a 500 MHz NMR Spectrometer at Jackson State University
REU Site: Interdisciplinary Research on Nanomaterials Based Environmental Sensing, Biological Application and Modeling for Underrepresented Minority Undergraduates
Purchase of Nanosecond Nd:YAG laser and Dye Laser System