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Michelle Chan‐Seng‐Yue

Ontario Institute for Cancer Research ·
Area of research
Cancer Research · Molecular Biology
Research interest
Research interests include Cancer Genomics and Diagnostics, Acute Lymphoblastic Leukemia research, Lung Cancer Treatments and Mutations, and Epigenetics and DNA Methylation.
h-index
45
citations
18,445
works
226
NIH funding
primary concept
Biology
email

Recent publications

Multipotent lineage potential in B cell acute lymphoblastic leukemia is associated with distinct cellular origins and clinical features
Nature Cancer 2025cited by 19position: middledoi
Response to Immune Checkpoint Blockade Is Enhanced in the Presence of Hematopoietic TET2 Inactivation
Cancer Research 2025cited by 2position: middledoi
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma
Cell Reports 2024cited by 67position: middledoi
Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy
bioRxiv (Cold Spring Harbor Laboratory) 2024cited by 3position: middledoi
A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia
Nature Medicine 2022cited by 332position: middledoi
Whole genome sequencing delineates regulatory, copy number, and cryptic splice variants in early onset cardiomyopathy
npj Genomic Medicine 2022cited by 39position: middledoi
A latent subset of human hematopoietic stem cells resists regenerative stress to preserve stemness
Nature Immunology 2021cited by 65position: middledoi
Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution
Nature Genetics 2020cited by 674position: firstdoi
Relapse-Fated Latent Diagnosis Subclones in Acute B Lineage Leukemia Are Drug Tolerant and Possess Distinct Metabolic Programs
Cancer Discovery 2020cited by 100position: middledoi
Dichotomous Regulation of Lysosomes By MYC and Tfeb Controls Hematopoietic Stem Cell Fate
Blood 2020cited by 3position: middledoi
Genomic hallmarks of localized, non-indolent prostate cancer
Nature 2017cited by 636position: middledoi
Association of Distinct Mutational Signatures With Correlates of Increased Immune Activity in Pancreatic Ductal Adenocarcinoma
JAMA Oncology 2016cited by 301position: middledoi
Spatial genomic heterogeneity within localized, multifocal prostate cancer
Nature Genetics 2015cited by 486position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

John E. Dick · University Health Network5 papers (2020–2025)Andy G.X. Zeng · University Health Network4 papers (2021–2025) · 3 papers (2020–2024)Véronique Voisin · University Health Network3 papers (2020–2025)Liqing Jin · University Health Network2 papers (2022–2024) · 2 papers (2021–2025)Stephanie Z. Xie · Monash University2 papers (2020–2021) · 2 papers (2020–2021) · 2 papers (2020–2021)Suraj Bansal · University Health Network2 papers (2022–2024) · 2 papers (2020–2021) · 2 papers (2020–2021) · 2 papers (2020–2021)Mark D. Minden · Toronto Public Health2 papers (2022–2024)Chunxu Qu · Jiangsu University1 papers (2025–2025) · 1 papers (2024–2024)Naval Daver · The University of Texas MD Anderson Cancer Center1 papers (2022–2022) · 1 papers (2024–2024)Matthew T. Witkowski · University of Colorado Denver1 papers (2025–2025)Brian Raught · University Health Network1 papers (2021–2021)