Area of research
Molecular Biology · Epidemiology
Research interest
Research interests include Ubiquitin and proteasome pathways, Protein Degradation and Inhibitors, Autophagy in Disease and Therapy, and Glycosylation and Glycoproteins Research.
NUB1 traps unfolded FAT10 for ubiquitin-independent degradation by the 26S proteasome
The deubiquitinase Rpn11 functions as an allosteric ubiquitin sensor to promote substrate engagement by the 26S proteasome
Structural landscape of the degrading 26S proteasome reveals conformation-specific binding of TXNL1
Mechanisms and regulation of substrate degradation by the 26S proteasome
The Ufd1 cofactor determines the linkage specificity of polyubiquitin chain engagement by the AAA+ ATPase Cdc48
Preparation of site-specifically fluorophore-labeled polyubiquitin chains for FRET studies of Cdc48 substrate processing
Ubiquitin modulates 26 <i>S</i> proteasome conformational dynamics and promotes substrate degradation
High-Throughput Assay for Characterizing Rpn11 Deubiquitinase Activity
The 26S Proteasome Utilizes a Kinetic Gateway to Prioritize Substrate Degradation
The Cdc48 unfoldase prepares well-folded protein substrates for degradation by the 26S proteasome
Understanding the 26S proteasome molecular machine from a structural and conformational dynamics perspective
Structure and Function of the 26S Proteasome
An AAA Motor-Driven Mechanical Switch in Rpn11 Controls Deubiquitination at the 26S Proteasome
Structures of Neutrophil Serine Protease 4 Reveal an Unusual Mechanism of Substrate Recognition by a Trypsin-Fold Protease