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Swetansu K. Hota

Indiana University School of Medicine · US
Area of research
Molecular Biology · Epidemiology
Research interest
Dr. Hota’s expertise is in chromatin structure and protein that modify chromatin and how they affect the activity of genes. His current goals are to delineate mechanism of how chromatin remodeling complexes determine cell fate during cell differentiation and organ development. His ultimate aim is to understand how mutations in these complexes lead to congenital heart defects and neurodevelopmental disorders.
h-index
14
citations
1,137
works
31
NIH funding
primary concept
email

Recent publications

A disrupted compartment boundary underlies abnormal cardiac patterning and congenital heart defects. Kathiriya IS, Dominguez MH, Rao KS, Muncie-Vasic JM, Devine WP, Hu KM, Hota SK, Garay BI, Quintero D, Goyal P, Matthews MN, Thomas R, Sukonnik T, Miguel-Perez D, Winchester S, Brower EF, Forjaz A, Wu
2024cited by 0position: selected
Brahma safeguards canalization of cardiac mesoderm differentiation
Nature 2022cited by 58position: firstdoi
Brahma safeguards canalization of cardiac mesoderm differentiation. Hota SK, Rao KS, Blair AP, Khalilimeybodi A, Hu KM, Thomas R, So K, Kameswaran V, Xu J, Polacco BJ, Desai RV, Chatterjee N, Hsu A, Muncie JM, Blotnick AM, Winchester SAB, Weinberger LS, Hüttenhain R, Kathiriya IS, Krogan NJ, Saucerm
2022cited by 0position: selected
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Kathiriya IS, Rao KS, Iacono G, Devine WP, Blair AP, Hota SK, Lai MH, Garay BI, Thomas R, Gong HZ, Wasson LK, Goyal P, Sukonnik T, Hu KM, Akgun GA, Bernard LD, Akerberg BN, Gu F, Li K, Speir ML, Haeussl
2021cited by 0position: selected
Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease
Developmental Cell 2020cited by 129position: middledoi
Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation. Bhardwaj SK, Hailu SG, Olufemi L, Brahma S, Kundu S, Hota SK, Persinger J, Bartholomew B. Nat Commun. 2020 11 20; 11(1):5913.
2020cited by 0position: selected
Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis
Development 2019cited by 67position: firstdoi
Dynamic BAF chromatin remodeling complex subunit inclusion promotes temporally distinct gene expression programs in cardiogenesis. Hota SK, Johnson JR, Verschueren E, Thomas R, Blotnick AM, Zhu Y, Sun X, Pennacchio LA, Krogan NJ, Bruneau BG. Development. 2019 07 05; 146(19).
2019cited by 0position: selected
Histone Octamer Structure Is Altered Early in ISW2 ATP-Dependent Nucleosome Remodeling. Hada A, Hota SK, Luo J, Lin YC, Kale S, Shaytan AK, Bhardwaj SK, Persinger J, Ranish J, Panchenko AR, Bartholomew B. Cell Rep. 2019 07 02; 28(1):282-294.e6.
2019cited by 0position: selected
Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function. Sun X, Hota SK, Zhou YQ, Novak S, Miguel-Perez D, Christodoulou D, Seidman CE, Seidman JG, Gregorio CC, Henkelman RM, Rossant J, Bruneau BG. Biol Open. 20
2018cited by 0position: selected
Cardiac-enriched BAF chromatin-remodeling complex subunit Baf60c regulates gene expression programs essential for heart development and function
Biology Open 2017cited by 50position: middledoi
ATP-dependent chromatin remodeling during mammalian development
Development 2016cited by 247position: firstdoi
ATP-dependent chromatin remodeling during mammalian development. Hota SK, Bruneau BG. Development. 2016 08 15; 143(16):2882-97.
2016cited by 0position: selected
Brg1 modulates enhancer activation in mesoderm lineage commitment
Development 2015cited by 102position: middledoi
Brg1 modulates enhancer activation in mesoderm lineage commitment. Alexander JM, Hota SK, He D, Thomas S, Ho L, Pennacchio LA, Bruneau BG. Development. 2015 Apr 15; 142(8):1418-30.
2015cited by 0position: selected
ISWI Remodelers Slide Nucleosomes with Coordinated Multi-Base-Pair Entry Steps and Single-Base-Pair Exit Steps
Cell 2013cited by 182position: middledoi
Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains
Nature Structural & Molecular Biology 2013cited by 74position: firstdoi
ISWI remodelers slide nucleosomes with coordinated multi-base-pair entry steps and single-base-pair exit steps. Deindl S, Hwang WL, Hota SK, Blosser TR, Prasad P, Bartholomew B, Zhuang X. Cell. 2013 Jan 31; 152(3):442-52.
2013cited by 0position: selected
Nucleosome mobilization by ISW2 requires the concerted action of the ATPase and SLIDE domains. Hota SK, Bhardwaj SK, Deindl S, Lin YC, Zhuang X, Bartholomew B. Nat Struct Mol Biol. 2013 Feb; 20(2):222-9.
2013cited by 0position: selected
Disparity in the DNA translocase domains of SWI/SNF and ISW2. Dechassa ML, Hota SK, Sen P, Chatterjee N, Prasad P, Bartholomew B. Nucleic Acids Res. 2012 May; 40(10):4412-21.
2012cited by 0position: selected
Approaches for studying nucleosome movement by ATP-dependent chromatin remodeling complexes. Hota SK, Bartholomew B. Methods Mol Biol. 2012; 809:367-80.
2012cited by 0position: selected
Mapping protein-DNA and protein-protein interactions of ATP-dependent chromatin remodelers. Hota SK, Dechassa ML, Prasad P, Bartholomew B. Methods Mol Biol. 2012; 809:381-409.
2012cited by 0position: selected
An assay for exogenous sources of purified MurG, enabled by the complementation of Escherichia coli murG(Ts) by the Mycobacterium tuberculosis homologue. Jha RK, Katagihallimath N, Hota SK, Das KS, de Sousa SM. FEMS Microbiol Lett. 2012 Jan; 326(2):161-7.
2012cited by 0position: selected

Grants

No grants ingested yet.

Frequent collaborators

Benoit G. Bruneau · Gladstone Institutes5 papers (2015–2022)Xin Sun · Hospital for Sick Children2 papers (2017–2019)Xiaowei Zhuang · Harvard University2 papers (2013–2013)Aaron M. Blotnick · University of California, Berkeley2 papers (2019–2022)Sebastian Deindl · Uppsala University2 papers (2013–2013) · 2 papers (2013–2013)Nevan J. Krogan · QB32 papers (2019–2022)Reuben Thomas · Gladstone Institutes2 papers (2019–2022)L Pennacchio · University of California, Berkeley2 papers (2015–2019)Ravi V. Desai · Gladstone Institutes1 papers (2022–2022)J M Alexander · Spark Therapeutics (United States)1 papers (2015–2015)Timothy R. Blosser · Broad Institute1 papers (2013–2013)Daniel He · National Institutes of Health1 papers (2015–2015)Leor S. Weinberger · University of Miami1 papers (2022–2022)Carol C. Gregorio · University of Arizona1 papers (2017–2017)William L. Hwang · Harvard University1 papers (2013–2013)Yiwen Zhu · Shanghai Medical College of Fudan University1 papers (2019–2019)Kevin So · Gladstone Institutes1 papers (2022–2022)Stefanie M. Novak · University of Arizona1 papers (2017–2017)Austin Hsu · Gladstone Institutes1 papers (2022–2022)