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Joshua W. Knowles

Cardiovascular Institute of the South ·
Area of research
Surgery · Genetics
Research interest
Research interests include Lipoproteins and Cardiovascular Health, Genetic Associations and Epidemiology, Diabetes, Cardiovascular Risks, and Lipoproteins, and Cancer, Lipids, and Metabolism.
h-index
68
citations
26,757
works
357
NIH funding
primary concept
email

Recent publications

Primary care providers’ perspectives on receiving opportunistic genomic results from a national study: The Million Veteran Program Return Of Actionable Results (MVP-ROAR) Study
Genetics in Medicine 2025cited by 1position: middledoi
Lac-Phe mediates the effects of metformin on food intake and body weight
Nature Metabolism 2024cited by 73position: middledoi
X chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction
Nature Communications 2024cited by 13position: middledoi
A functional genomic framework to elucidate novel causal metabolic dysfunction–associated fatty liver disease genes
Hepatology 2024cited by 13position: lastdoi
Trends of Lipid Concentrations, Awareness, Evaluation, and Treatment in Severe Dyslipidemia in US Adults
Mayo Clinic Proceedings 2024cited by 9position: middledoi
RNA Interference Therapy Targeting Apolipoprotein C-III in Hypertriglyceridemia
NEJM Evidence 2023cited by 68position: middledoi
Contemporary Homozygous Familial Hypercholesterolemia in the United States: Insights From the CASCADE FH Registry
Journal of the American Heart Association 2023cited by 47position: middledoi
Introducing return of results in the Million Veteran Program: Design and pilot results of the MVP-ROAR Familial Hypercholesterolemia Study
medRxiv 2023cited by 0position: middledoi
Ultrarapid Nanopore Genome Sequencing in a Critical Care Setting
New England Journal of Medicine 2022cited by 216position: middledoi
Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
Cell Metabolism 2021cited by 129position: middledoi
Identification of rare and common regulatory variants in pluripotent cells using population-scale transcriptomics
Nature Genetics 2021cited by 75position: middledoi
Properties of structural variants and short tandem repeats associated with gene expression and complex traits
Nature Communications 2020cited by 136position: middledoi
FAM13A affects body fat distribution and adipocyte function
Nature Communications 2020cited by 64position: lastdoi
Abstract 15751: Pharmacodynamic Effect of ARO-ANG3, an Investigational RNA Interference Targeting Hepatic Angiopoietin-like Protein 3, in Patients With Hypercholesterolemia
Circulation 2020cited by 40position: middledoi
Discovery and quality analysis of a comprehensive set of structural variants and short tandem repeats
Nature Communications 2020cited by 36position: middledoi
Children with Heterozygous Familial Hypercholesterolemia in the United States: Data from the Cascade Screening for Awareness and Detection-FH Registry
The Journal of Pediatrics 2020cited by 27position: middledoi
Predictive network modeling in human induced pluripotent stem cells identifies key driver genes for insulin responsiveness
PLoS Computational Biology 2020cited by 20position: middledoi
Clinical Genetic Testing for Familial Hypercholesterolemia
Journal of the American College of Cardiology 2018cited by 587position: middledoi
Distance to treatment as a factor for loss to follow up of hepatitis C patients in North East England
Journal of Public Health 2018cited by 20position: middledoi
Health disparities among adult patients with a phenotypic diagnosis of familial hypercholesterolemia in the CASCADE-FH™ patient registry
Atherosclerosis 2017cited by 99position: middledoi
Human induced pluripotent stem cell–derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
Nature Medicine 2016cited by 753position: middledoi
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity
Cell stem cell 2016cited by 278position: middledoi
Association Between Intensity of Statin Therapy and Mortality in Patients With Atherosclerotic Cardiovascular Disease
JAMA Cardiology 2016cited by 161position: middledoi
US physician practices for diagnosing familial hypercholesterolemia: data from the CASCADE-FH registry
Journal of clinical lipidology 2016cited by 84position: lastdoi
Interdisciplinary psychosocial care for families with inherited cardiovascular diseases
Trends in Cardiovascular Medicine 2016cited by 72position: middledoi
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene
Journal of Clinical Investigation 2015cited by 155position: firstdoi
Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
Diabetes 2014cited by 227position: middledoi
Reducing the burden of disease and death from familial hypercholesterolemia: A call to action
American Heart Journal 2014cited by 66position: firstdoi
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
Diabetes 2013cited by 379position: middledoi
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
Nature Genetics 2013cited by 319position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

· 7 papers (2016–2024)Thomas Quertermous · Cardiovascular Institute of the South6 papers (2016–2024)Christie M. Ballantyne · New York University3 papers (2013–2023)Emily C. O’Brien · Duke University3 papers (2013–2020)Martin Wabitsch · Universität Ulm3 papers (2020–2021)Stephen B. Montgomery · Stanford Medicine3 papers (2020–2020)Katherine Wilemon · University of Nevada, Reno3 papers (2013–2020) · 2 papers (2023–2025)Erin N. Smith · Takeda (United States)2 papers (2020–2020)Davis J. McCarthy · The University of Melbourne2 papers (2020–2020)Robert A. Hegele · Western University2 papers (2020–2023)Kuixi Zhu · University of Arizona2 papers (2016–2020)Yan V. Sun · Utah State University2 papers (2023–2025)Kurt D. Christensen · Harvard University2 papers (2023–2025)Na Cai · Helmholtz-Institute Ulm2 papers (2020–2020)Pradeep Natarajan · Broad Institute2 papers (2023–2024)Daniel D. Seaton · University of Edinburgh2 papers (2020–2020)Matteo D’Antonio · University of Washington2 papers (2020–2020)David Jakubosky · University of California San Diego2 papers (2020–2020) · 2 papers (2013–2020)