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Lars Mäegdefessel

TUM Klinikum · DE
Area of research
Cancer Research · Pulmonary and Respiratory Medicine
Research interest
Research interests include Aortic aneurysm repair treatments, Cancer-related molecular mechanisms research, Atherosclerosis and Cardiovascular Diseases, and MicroRNA in disease regulation.
h-index
59
citations
11,511
works
411
NIH funding
primary concept
Medicine
email

Recent publications

Ezh2 Shapes T Cell Plasticity to Drive Atherosclerosis
Circulation 2025cited by 17position: middledoi
MicroRNA-15a-5p mediates abdominal aortic aneurysm progression and serves as a potential diagnostic and prognostic circulating biomarker
Communications Medicine 2025cited by 9position: lastdoi
Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease
European Heart Journal 2025cited by 9position: middledoi
CXCL12 Derived From ACKR1 <sup>+</sup> Intraplaque Neovessels Mediates CD8 <sup>+</sup> T Cell Recruitment in Human Atherosclerosis
Circulation 2025cited by 7position: middledoi
Single cell spatial transcriptomics integration deciphers the morphological heterogeneity of atherosclerotic carotid arteries
Nature Communications 2025cited by 7position: lastdoi
Abstract 4367749: Cancer Accelerates Atherosclerosis via a TNF-Driven Angiogenic Pathway
Circulation 2025cited by 0position: middledoi
Atherosclerosis Is a Smooth Muscle Cell–Driven Tumor-Like Disease
Circulation 2024cited by 112position: middledoi
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
Arteriosclerosis Thrombosis and Vascular Biology 2024cited by 88position: middledoi
Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis
Nature Cardiovascular Research 2024cited by 39position: middledoi
Pro-efferocytic nanotherapies reduce vascular inflammation without inducing anemia in a large animal model of atherosclerosis
Nature Communications 2024cited by 26position: middledoi
Inflammatory crosstalk impairs phagocytic receptors and aggravates atherosclerosis in clonal hematopoiesis in mice
Journal of Clinical Investigation 2024cited by 23position: middledoi
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
Molecular Metabolism 2024cited by 22position: middledoi
PIEZO1 targeting in macrophages boosts phagocytic activity and foam cell apoptosis in atherosclerosis
Cellular and Molecular Life Sciences 2024cited by 22position: middledoi
Myeloid cannabinoid CB1 receptor deletion confers atheroprotection in male mice by reducing macrophage proliferation in a sex-dependent manner
Cardiovascular Research 2024cited by 6position: middledoi
Abstract 4145859: Clonal Hematopoiesis of Indeterminate Potential Increases Mortality Risk in Coronary Artery Disease
Circulation 2024cited by 0position: middledoi
<i>INKILN</i> is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10
Circulation 2023cited by 59position: middledoi
Vascular smooth muscle–specific YAP/TAZ deletion triggers aneurysm development in mouse aorta
JCI Insight 2023cited by 38position: middledoi
Utilization of an Artery‐on‐a‐Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases
Advanced Healthcare Materials 2023cited by 35position: lastdoi
Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression
Molecular Therapy 2023cited by 29position: lastdoi
Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing
Atherosclerosis 2023cited by 16position: middledoi
Abstract 128: Safety And Efficacy Of Pro-efferocytic Nanoparticles To Treat Atherosclerosis In A Porcine Model
Arteriosclerosis Thrombosis and Vascular Biology 2023cited by 0position: middledoi
Safety and Efficacy of Proefferocytic Nanoparticles to Treat Atherosclerosis in a Porcine Model
JVS Vascular Science 2023cited by 0position: middledoi
Interferon regulatory factor-5-dependent CD11c+ macrophages contribute to the formation of rupture–prone atherosclerotic plaques
European Heart Journal 2022cited by 83position: middledoi
miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages
Circulation Research 2022cited by 70position: middledoi
Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart
Utrecht University Repository (Utrecht University) 2022cited by 66position: middle
The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis
Nature Cardiovascular Research 2022cited by 54position: middledoi
GPR55 in B cells limits atherosclerosis development and regulates plasma cell maturation
Nature Cardiovascular Research 2022cited by 19position: middledoi
Targeting PIEZO1 Refines Macrophage Function in Atherosclerosis
SSRN Electronic Journal 2022cited by 1position: middledoi
Targeting PIEZO1 refines macrophage function in atherosclerosis
Research Square 2022cited by 1position: middledoi
Acute mental stress drives vascular inflammation and promotes plaque destabilization in mouse atherosclerosis
European Heart Journal 2021cited by 124position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Ulf Hedin · Karolinska Institutet22 papers (2014–2024)Ekaterina Chernogubova · Karolinska Institutet14 papers (2015–2025)Hong Jin · Karolinska Institutet13 papers (2014–2025)Ljubica Matic · Karolinska Institutet12 papers (2016–2024)Nicholas J. Leeper · Cardiovascular Institute of the South9 papers (2014–2022)Suzanne M. Eken · Karolinska Institutet9 papers (2014–2025)Philip S. Tsao · Stanford University9 papers (2012–2025)Ljubica Perisic · Karolinska University Hospital9 papers (2014–2018)Joshua M. Spin · Stanford University9 papers (2012–2025)Nadja Sachs · Technical University of Munich9 papers (2023–2025)Alexandra Bäcklund · Cornell University8 papers (2016–2025)Hanna Winter · TUM Klinikum8 papers (2018–2025)Reinier A. Boon · Goethe University Frankfurt8 papers (2018–2025)Uwe Raaz · Nephrologisches Zentrum Goettingen7 papers (2013–2018)Jianqin Ye · Stanford University7 papers (2015–2023)Jessica Pauli · Technical University of Munich7 papers (2021–2025)Yuhuang Li · Zunyi Medical University7 papers (2015–2024)Yoko Kojima · University of Virginia7 papers (2014–2023)Hans‐Henning Eckstein · TUM Klinikum7 papers (2016–2025)Christian Weber · Dana-Farber Cancer Institute6 papers (2019–2025)