Area of research
Molecular Biology · Oncology
Research interest
Research interests include Cancer-related Molecular Pathways, Protein Degradation and Inhibitors, Cancer Research and Treatments, and Ubiquitin and proteasome pathways.
Stabilization of GTSE1 by cyclin D1–CDK4/6-mediated phosphorylation promotes cell proliferation with implications for cancer prognosis
CDK-independent role of D-type cyclins in regulating DNA mismatch repair
CRL4AMBRA1 is a master regulator of D-type cyclins
AMBRA1 regulates cyclin D to guard S-phase entry and genomic integrity
Loss of FBXO31-mediated degradation of DUSP6 dysregulates ERK and PI3K-AKT signaling and promotes prostate tumorigenesis
The Long-Lost Ligase: CRL4 <sup>AMBRA1</sup> Regulates the Stability of D-Type Cyclins
PHOTACs enable optical control of protein degradation
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster
Epigenetic silencing of the ubiquitin ligase subunit FBXL7 impairs c-SRC degradation and promotes epithelial-to-mesenchymal transition and metastasis
The ULK1-FBXW5-SEC23B nexus controls autophagy
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
The TDH–GCN5L1–Fbxo15–KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells