Area of research
Molecular Biology
Research interest
Research focused on Cell biology and RNA polymerase II, with related work in Protein subunit, Proteostasis, Ribonucleotide reductase. Notable publications include 'Cytosolic proteostasis through importing of misfolded proteins into mitochondria', 'Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair', and 'Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping'.
Distinct states of nucleolar stress induced by anticancer drugs
A putative cap binding protein and the methyl phosphate capping enzyme Bin3/MePCE function in telomerase biogenesis
Decellularization Enables Characterization and Functional Analysis of Extracellular Matrix in Planarian Regeneration
Dynamic RNA acetylation revealed by quantitative cross-evolutionary mapping
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation
The ULK1-FBXW5-SEC23B nexus controls autophagy
dCas9-targeted locus-specific protein isolation method identifies histone gene regulators
Cytosolic proteostasis through importing of misfolded proteins into mitochondria
PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth
The human cytoplasmic dynein interactome reveals novel activators of motility
Mediator structure and rearrangements required for holoenzyme formation
The TDH–GCN5L1–Fbxo15–KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells
The WHHERE coactivator complex is required for retinoic acid-dependent regulation of embryonic symmetry
SONAR Discovers RNA-Binding Proteins from Analysis of Large-Scale Protein-Protein Interactomes
Trio, a Rho Family GEF, Interacts with the Presynaptic Active Zone Proteins Piccolo and Bassoon
The Integrator complex controls the termination of transcription at diverse classes of gene targets
The membrane-associated proteins FCHo and SGIP are allosteric activators of the AP2 clathrin adaptor complex
Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing
FBXL2- and PTPL1-mediated degradation of p110-free p85β regulatory subunit controls the PI(3)K signalling cascade
Regulation of the CRL4Cdt2 Ubiquitin Ligase and Cell-Cycle Exit by the SCFFbxo11 Ubiquitin Ligase
FBH1 promotes DNA double-strand breakage and apoptosis in response to DNA replication stress
Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair
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