Area of research
Hematology · Genetics
Research interest
Research interests include Acute Myeloid Leukemia Research, Myeloproliferative Neoplasms: Diagnosis and Treatment, Epigenetics and DNA Methylation, and Chronic Myeloid Leukemia Treatments.
RNA m5C oxidation by TET2 regulates chromatin state and leukaemogenesis
DDX18 coordinates nucleolus phase separation and nuclear organization to control the pluripotency of human embryonic stem cells
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal
Loss of BRD4 induces cell senescence in HSC/HPCs by deregulating histone H3 clipping
Targeting lysine demethylase 6B ameliorates ASXL1 truncation–mediated myeloid malignancies in preclinical models
HOTTIP-dependent R-loop formation regulates CTCF boundary activity and TAD integrity in leukemia
HOXBLINC long non-coding RNA activation promotes leukemogenesis in NPM1-mutant acute myeloid leukemia
p300 suppresses the transition of myelodysplastic syndromes to acute myeloid leukemia
INTS11 regulates hematopoiesis by promoting PRC2 function
Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia
HOTTIP lncRNA Promotes Hematopoietic Stem Cell Self-Renewal Leading to AML-like Disease in Mice
ASXL1 alteration cooperates with JAK2V617F to accelerate myelofibrosis
<i>Six1</i> regulates leukemia stem cell maintenance in acute myeloid leukemia
RNA-dependent chromatin targeting of TET2 for endogenous retrovirus control in pluripotent stem cells
CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia
CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis
A novel ASXL1–OGT axis plays roles in H3K4 methylation and tumor suppression in myeloid malignancies
Cardiac Sca-1 <sup>+</sup> Cells Are Not Intrinsic Stem Cells for Myocardial Development, Renewal, and Repair
Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates
Tet2 Regulates Osteoclast Differentiation by Interacting with Runx1 and Maintaining Genomic 5-Hydroxymethylcytosine (5hmC)
Reduced BAP1 activity prevents ASXL1 truncation-driven myeloid malignancy in vivo
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression
Gain of function of ASXL1 truncating protein in the pathogenesis of myeloid malignancies
Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
<i>PBX3</i> is essential for leukemia stem cell maintenance in <i>MLL</i>‐rearranged leukemia
Caspase-3 controls AML1-ETO–driven leukemogenesis via autophagy modulation in a ULK1-dependent manner
TET2 Loss Dysregulates the Behavior of Bone Marrow Mesenchymal Stromal Cells and Accelerates Tet2-Driven Myeloid Malignancy Progression
ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis
Tyrosine kinase inhibitors targeting FLT3 in the treatment of acute myeloid leukemia