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Sophie Hambleton

Newcastle upon Tyne Hospitals NHS Foundation Trust · GB
Area of research
Immunology · Hematology
Research interest
Research interests include Immunodeficiency and Autoimmune Disorders, Immune Cell Function and Interaction, T-cell and B-cell Immunology, and Hematopoietic Stem Cell Transplantation.
h-index
63
citations
15,828
works
248
NIH funding
primary concept
Medicine
email

Recent publications

Human inborn errors of immunity: 2024 update on the classification from the International Union of Immunological Societies Expert Committee
Journal of Human Immunity 2025cited by 217position: middledoi
The 2024 update of IUIS phenotypic classification of human inborn errors of immunity
Journal of Human Immunity 2025cited by 108position: middledoi
Rare disease gene association discovery in the 100,000 GenomesProject
Nature 2025cited by 16position: middledoi
Diagnostic evaluation of paediatric autoimmune lymphoproliferative immunodeficiencies (ALPID): a prospective cohort study
The Lancet Haematology 2024cited by 18position: middledoi
Human inherited complete STAT2 deficiency underlies inflammatory viral diseases
Journal of Clinical Investigation 2023cited by 46position: middledoi
Stretch-activated ion channel TMEM63B associates with developmental and epileptic encephalopathies and progressive neurodegeneration
The American Journal of Human Genetics 2023cited by 40position: middledoi
Systemic Inflammation and Normocytic Anemia in DOCK11 Deficiency
New England Journal of Medicine 2023cited by 32position: middledoi
Precision medicine in monogenic inflammatory bowel disease: proposed mIBD REPORT standards
Nature Reviews Gastroenterology & Hepatology 2023cited by 20position: middledoi
Monogenic early-onset lymphoproliferation and autoimmunity: Natural history of STAT3 gain-of-function syndrome
Journal of Allergy and Clinical Immunology 2022cited by 119position: middledoi
Human CARMIL2 deficiency underlies a broader immunological and clinical phenotype than CD28 deficiency
The Journal of Experimental Medicine 2022cited by 37position: middledoi
Single-cell multi-omics analysis of the immune response in COVID-19
Nature Medicine 2021cited by 822position: middledoi
Immunogenicity of standard and extended dosing intervals of BNT162b2 mRNA vaccine
Cell 2021cited by 352position: middledoi
The expansion of human T-bet <sup>high</sup> CD21 <sup>low</sup> B cells is T cell dependent
Science Immunology 2021cited by 144position: middledoi
Therapeutic options for CTLA-4 insufficiency
Journal of Allergy and Clinical Immunology 2021cited by 118position: middledoi
Hematopoietic Cell Transplantation Cures Adenosine Deaminase 2 Deficiency: Report on 30 Patients
Journal of Clinical Immunology 2021cited by 73position: middledoi
An essential role for the Zn2+ transporter ZIP7 in B cell development
Nature Immunology 2019cited by 131position: lastdoi
Phenotype, penetrance, and treatment of 133 cytotoxic T-lymphocyte antigen 4–insufficient subjects
Journal of Allergy and Clinical Immunology 2018cited by 431position: middledoi
Hypomorphic caspase activation and recruitment domain 11 (CARD11) mutations associated with diverse immunologic phenotypes with or without atopic disease
Journal of Allergy and Clinical Immunology 2018cited by 147position: middledoi
Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency
Nature Immunology 2018cited by 115position: middledoi
PEPtalk2: results of a pilot randomised controlled trial to compare VZIG and aciclovir as postexposure prophylaxis (PEP) against chickenpox in children with cancer
Archives of Disease in Childhood 2018cited by 12position: middledoi
Somatic STAT5b gain-of-function mutations in early onset nonclonal eosinophilia, urticaria, dermatitis, and diarrhea
Blood 2016cited by 107position: middledoi
Hematopoietic stem cell transplant in patients with activated PI3K delta syndrome
Journal of Allergy and Clinical Immunology 2016cited by 105position: middledoi
Dedicator of cytokinesis 8–deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells
Journal of Allergy and Clinical Immunology 2016cited by 98position: middledoi
Unique and shared signaling pathways cooperate to regulate the differentiation of human CD4+ T cells into distinct effector subsets
The Journal of Experimental Medicine 2016cited by 87position: middledoi
Varicella zoster virus infection
Nature Reviews Disease Primers 2015cited by 861position: middledoi
Impairment of immunity to <i>Candida</i> and <i>Mycobacterium</i> in humans with bi-allelic <i>RORC</i> mutations
Science 2015cited by 414position: middledoi
Early-Onset Stroke and Vasculopathy Associated with Mutations in ADA2
New England Journal of Medicine 2014cited by 884position: middledoi
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
Blood 2014cited by 551position: middledoi
Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8K108E mutation
Blood 2014cited by 75position: middledoi
Abnormally differentiated CD4+ or CD8+ T cells with phenotypic and genetic features of double negative T cells in human Fas deficiency
Blood 2014cited by 63position: middledoi

Grants

No grants ingested yet.

Frequent collaborators

Stuart G. Tangye · Garvan Institute of Medical Research3 papers (2016–2025)Helen C. Su · ActionAid3 papers (2016–2025)Stephan Ehl · Rockefeller University2 papers (2014–2016)Isabelle Meyts · KU Leuven2 papers (2025–2025)Tomohiro Morio · Rockefeller University2 papers (2025–2025) · 2 papers (2025–2025)Jean‐Laurent Casanova · Tehran University of Medical Sciences2 papers (2014–2016)Ahmed Aziz Bousfiha · Mother Hospital2 papers (2025–2025)Anne Puel · Inserm2 papers (2025–2025)Capucine Pïcard · Hôpital Necker-Enfants Malades2 papers (2025–2025)Alexandra F. Freeman · National Institutes of Health2 papers (2016–2016)Judith Breuer · Great Ormond Street Hospital2 papers (2015–2018)Troy R. Torgerson · Allen Institute for Immunology2 papers (2025–2025)Mikko Seppänen · University of Helsinki2 papers (2025–2025)Mario Abinun · Newcastle University2 papers (2014–2016)Christoph Klein · Freie Universität Berlin2 papers (2025–2025)Andrew J. Cant · Clinical Research Institute2 papers (2014–2016) · 2 papers (2025–2025)Charlotte Cunningham‐Rundles · Child Health and Development Institute2 papers (2025–2025)Ivona Aksentijevich · National Institutes of Health2 papers (2025–2025)